UCL Cancer Institute


UCL Cancer Institute Seminar Series

01 March 2017, 12:00 pm–1:00 pm

alexandra snyder…

Dr Alexandra Snyder, Memorial Sloan Kettering Cancer Centre, New York, presents: Where next?: themes and unanswered questions in immunotherapy-treated solid tumours.

Event Information


UCL Cancer Institute, Paul O'Gorman Building

Chromosomal instability (CIN) is a hallmark of human neoplasms. Our recent understanding of the mechanisms of CIN in cancer has enabled us to dissect its role in tumour evolution. It is now increasingly evident that CIN is not a bystander event in tumorigenesis but it plays a critical role in clonal heterogeneity, drug resistance, and metastasis.

Hosted by: Dr Sergio Quezada

Checkpoint blockade immunotherapy agents have substantially improved outcomes for a subset of patients with metastatic solid tumors.  Exonic mutation burden demonstrates an imperfect association with response to checkpoint blockade in melanoma, non-small cell lung cancers (NSCLC), urothelial cancers and mismatch repair-deficient malignancies. Similarly, tumor or immune cell PD-L1 staining appears to increase the probability of response to PD-1 or PD-L1-targeting agents in some tumor types but not others. First, the consistent themes, exceptions and challenges to the interpretation and application of these biomarkers will be discussed. Second, the integration of tumor somatic and immune features will be addressed. This field is at its inception; studies to date demonstrate inter- and intrapatient tumor and tumor microenvironment (TME) heterogeneity. Furthermore, the investigation of a cohort of patients with urothelial cancers treated with the anti-PD-L1 agent atezolizumab demonstrates an interaction between prognostic markers, immune and tumor biomarkers in this setting. These results demonstrate the compelling need for greater interrogation and data integration of tumor, TME and host immune factors that contribute to benefit and resistance to checkpoint blockade.

For more information, go to www.mskcc.org/cancer-care/doctors/alexandra-snyder-charen

The seminar will be followed by a sandwich buffet lunch.


Courtyard Café
UCL Cancer Institute
Paul O'Gorman Building
London, WC1E 6DD

Contact: Veronica Dominguez v.dominguez@ucl.ac.uk

This seminar has been part-sponsored by the NIHR UCLH Biomedical Research Centre and Cancer Research UK.