Online: CRUK RadNet City of London Seminar Series

Hosted by Dr Simon Boulton,
Group Leader at the Crick and Radiation Resistance Theme Lead

Speaker

Professor Roger Greenberg investigates basic mechanisms of DNA repair that impact cancer etiology and response to therapy.

His major research interests center on (1) the molecular basis of DNA double-strand break recognition and repair by the breast cancer suppressor proteins BRCA1 and BRCA2, and (2) noncanonical DNA repair mechanisms that become exaggerated in cancers harboring BRCA mutations and in those that rely on alternative telomere maintenance. He has developed novel methodologies at the single-cell and molecule levels to visualize all major steps of homologous recombination in real-time, discovered chromatin mechanisms that are responsible for responses to PARP inhibition, and showed that inherited biallelic BRCA1 mutations are causative for Fanconi Anemia.

Recently, his investigations have expanded to communication between DNA damage and immune responses. This revealed that mitotic progression following DNA damage enables pattern recognition of missegregated DNA in the cytoplasm to drive inflammatory stimulated gene expression that elicits anti-tumor immune responses.

• View pre-seminar Q&A with Roger Greenberg