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Online: CRUK-UCL Multidisciplinary Seminar Series

09 September 2020, 12:00 pm–1:00 pm

Multidisciplinary seminar Rob De Bruin and Marc Mansour

Professor Rob De Bruin, Medical Research Council Laboratory for Molecular Cell Biology (MRC LMCB) and Dr Marc Mansour, UCL Cancer Institute and UCLH present: 'Replication stress and cancer: a cause and therapeutic opportunity.'

Event Information

Open to

All

Availability

Yes

Organiser

CRUK-UCL Centre

Abstract

Oncogene-induced replication stress is a crucial driver of genomic instability and one of the key events contributing to the onset of cancer. Despite its proven role in cancer-initiation and development, the mechanisms underlying oncogene-induced replicative stress and the ability of cancer cells to tolerate these high levels of replication stress remain poorly understood.

Work carried out in the de Bruin and Mansour labs focuses on how cancer associated mutations cause replication stress and identify proteins involved in the tolerance to replication stress. This will help guide the use of existing cancer treatments, identify novel cancer drug targets, and help to define the best therapeutic window in which to target pathways to selectively kill cancer cells experiencing high levels of replication stress.

This is an online seminar using Zoom. If you would to join, please email Emily McLean on ci.crukcentre@ucl.ac.uk


Further information


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