Online: CRUK-UCL Multidisciplinary Seminar Series
09 September 2020, 12:00 pm–1:00 pm
Professor Rob De Bruin, Medical Research Council Laboratory for Molecular Cell Biology (MRC LMCB) and Dr Marc Mansour, UCL Cancer Institute and UCLH present: 'Replication stress and cancer: a cause and therapeutic opportunity.'
Event Information
Open to
- All
Availability
- Yes
Organiser
-
CRUK-UCL Centre
Abstract
Oncogene-induced replication stress is a crucial driver of genomic instability and one of the key events contributing to the onset of cancer. Despite its proven role in cancer-initiation and development, the mechanisms underlying oncogene-induced replicative stress and the ability of cancer cells to tolerate these high levels of replication stress remain poorly understood.
Work carried out in the de Bruin and Mansour labs focuses on how cancer associated mutations cause replication stress and identify proteins involved in the tolerance to replication stress. This will help guide the use of existing cancer treatments, identify novel cancer drug targets, and help to define the best therapeutic window in which to target pathways to selectively kill cancer cells experiencing high levels of replication stress.
Further information
- Mansour Lab - Leukaemia Biology Research
- De Bruin Lab - Cell Cycle Regulated Transcription and Genome Integrity
- UCL News: Cellular mechanism discovery offers potential treatment target for high-risk T-ALL
- Research paper: EZH2 deficient T-cell acute lymphoblastic leukemia is sensitized to CHK1 inhibition through enhanced replication stress. Cancer Discovery
UCL news
Cellular mechanism discovery offers potential treatment target for high-risk T-ALL
Researchers at UCL have discovered a novel cellular mechanism in a type of high-risk T-cell acute lymphoblastic leukaemia (T-ALL) that could be targeted with a checkpoint kinase inhibitor drug to help treat the disease.