Online: CRUK-UCL Multidisciplinary Seminar Series

Abstract

The genomes within somatic cells are constantly undergoing changes through mutational processes that affect the information and structure of the chromosomal sequences. These processes underlie ageing, disease and evolution; in cancer they give rise to intra-tumour heterogeneity and drug tolerance.

Work performed in the Barnes and Secrier labs employs various statistical modelling and analytic approaches to understand how these mutational processes arise and shape the trajectories of tumour evolution. Methods to infer evolutionary parameters, subclonal tumour architecture, chromosomal instability and dynamics of mutational processes from pre-cancerous stages to advanced cancers will be discussed.

Further information

• Dr Maria Secrier academic profile
• Prof Chris Barnes academic profile
• UCL Biosciences