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Cancer Institute Seminar Series - Prof Dario Alessi

12 November 2019, 10:45 am

Prof Dario Alessi

Prof Dario Alessi, Dundee University, presents: 'Analysis of the hVPS34-SGK3 signalling pathway.'

Event Information

Open to

All

Organiser

Veronica Dominguez

Location

Courtyard Cafe
UCL Cancer Institute 72 Huntley Street
London
WC1E 6DD

Hosted by: Dr Pablo Rodriguez-Viciana
 
A light lunch will be served after the seminar. 
 
Derailment of the PI3K-AGC protein kinase signalling network contributes to many human diseases. Recent work has revealed that the poorly studied AGC kinase family member, SGK3, promotes resistance to cancer therapies that target the Class 1 PI3K pathway, by substituting for loss of Akt kinase activity. SGK3 is recruited and activated at endosomes, by virtue of its phox homology domain binding to PtdIns(3)P. In my talk I will present the data we have showing endogenous SGK3 is rapidly activated by growth factors such as IGF1, through pathways involving both Class 1 and Class 3 PI3K (hVPS34). I will discuss the work we have done to identify and characterize a new set of selective SGK3 endosomally localised substrates that are not phosphorylated by Akt. I will also present new chemical tools we have generated to induce degradation of hVPS34 and SGK3 through using a PROTAC (A proteolysis targeting chimera).

Further information

 
This seminar has been sponsored in part by the Biomedical Research Centre and Cancer Research UK