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Cancer Institute Seminar Series - Dr Rahul Roychoudhuri

28 November 2018, 4:00 pm–5:00 pm

Dr Rahul Roychoudhuri

Dr Rahul Roychoudhuri,The Babraham Institute, Cambridge, presents:’Molecular mechanisms of T cell immunosuppression in cancer.’

Event Information

Open to

All

Organiser

Veronica Dominguez

Location

Courtyard Cafe
72 Huntley Street
London
WC1E 6DD

Hosted by Prof Sergio Quezada

The adaptive immune system employs a variety of suppressive mechanisms, collectively referred to as tolerance mechanisms, to restrain excessive immune activation that would otherwise result in autoimmunity and allergy. While tolerance mechanisms therefore play a beneficial role in preventing inflammation, they can also powerfully suppress immune responses during chronic infections and cancer in a process referred to as immunosuppression. T cells play a critical role coordinating immune function and whereas effector T cells drive immune activation and can drive rejection of cancer, their function is suppressed both by intrinsic inhibitory factors, components of the tumour microenvironment and specialised suppressive cells within the immune system, including CD4+ regulatory T cells. Effector and regulatory T cells arise from common precursors and yet establish dichotomous function. We are interested in how transcription factors drive acquisition of the dichotomous functional characteristics of effector and regulatory T cells and how this activity is affected during cancer. We have identified new molecular mechanisms that underpin tumour immunosuppression providing targets for development of new therapies aimed at reversing dysfunctional immune responses in cancer.

For more information visit: www.babraham.ac.uk/our-research/lymphocyte/rahul-roychoudhuri

This seminar has been sponsored in part by the Biomedical Research Centre and Cancer Research UK

Main image: 

Dr Rahul Roychoudhuri in his laboratory at the Babraham Institute, Cambridge. Credit: Jonathan Lawson