UCL Cancer Institute Seminar Series

There are over 140 known modifications of RNA, but for most of these a function is not known. We are developing assays and reagents for the analysis of several of these, with emphasis on the characterisation of methylation pathways leading to gene regulation. We have also generated a CRISP screen for RNA modifying enzymes involved in AML-leukaemia, and have identified 29 high confidence targets. For one of these RNA enzymes, we show that it is required for leukaemia in model systems and have identified a novel mechanism by which it acts to regulate gene expression.

The seminar will be followed by a sandwich buffet lunch.

Hosted by: Dr Richard Jenner

Location

UCL Cancer Institute
Courtyard Café
72 Huntley Street
London, WC1E 6DD

Contact: Veronica Dominguez v.dominguez@ucl.ac.ukView Map

This seminar has been sponsored in part by the Biomedical Research Centre and Cancer Research UK.