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UCL Cancer Institute Seminar Series

25 May 2017, 12:00 pm–1:00 pm

Professor Owen Sansom, Beatson Institute Glasgow, presents: Using GEMM models of colorectal cancer to explore new and old therapeutic targets.

Event Information

Location

UCL Cancer Institute, 72 Huntley Street

Colorectal cancer is the third most common cancer in the UK and the second most common cause of cancer mortality. The focus of our group is to understand the early changes associated with intestinal neoplasia in order to identify novel markers of the disease as well as new targets for therapy. The key intestinal tumour suppressor is the APC gene that is mutated in approximately 80% of sporadic cancers. Central to our work is the use of novel inducible models of intestinal tumorigenesis that allow us to study the functions of specific tumour suppressor genes.

Professor Sansom academic profile

Selected publications:

Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis AE, Sansom OJ. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature. 2015 Jan 22;517(7535):497-500. doi: 10.1038/nature13896.

Huels DJ, Ridgway RA, Radulescu S, Leushacke M, Campbell AD, Biswas S, Leedham S, Serra S, Chetty R, Moreaux G, Parry L, Matthews J, Song F, Hedley A, Kalna G, Ceteci F, Reed KR, Meniel VS, Maguire A, Doyle B, Söderberg O, Barker N, Watson A, Larue L, Clarke AR, Sansom OJ. E-cadherin can limit the transforming properties of activating β-catenin mutations. EMBO J. 2015 Sep 14;34(18):2321-33. doi: 10.15252/embj.201591739.

Steele CW, Karim SA, Leach JD, Bailey P, Upstill-Goddard R, Rishi L, Foth M, Bryson S, McDaid K, Wilson Z, Eberlein C, Candido JB, Clarke M, Nixon C, Connelly J, Jamieson N, Carter CR, Balkwill F, Chang DK, Evans TR, Strathdee D, Biankin AV, Nibbs RJ, Barry ST, Sansom OJ, Morton JP. CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma. Cancer Cell. 2016 Jun 13;29(6):832-45. doi: 10.1016/j.ccell.2016.04.014

Hosted by: Professor Bart Vanhaesebroeck

The seminar will be followed by a sandwich buffet lunch.  


Location

UCL Cancer Institute
Courtyard Café
72 Huntley Street
London, WC1E 6DD

Contact: Veronica Dominguez v.dominguez@ucl.ac.ukView Map

This seminar has been sponsored in part by Merck, the Biomedical Research Centre and Cancer Research UK