CRUK City of London Centre

The Cancer Research UK City of London (CoL) Centre is a world class hub for cancer biotherapeutics. It brings together researchers from four of the central London Cancer Research UK Centres: UCL, King’s College London, Barts / Queen Mary University of London and The Francis Crick Institute. This unique interdisciplinary and collaborative network will generate novel innovative biological therapies, diagnostics and stratification strategies in addition to providing a clinical and translational pipeline for cancer discovery science.

Biotherapies delivered as part of a multimodal / combinatorial approach have the potential to dramatically change cancer therapy and management. The CRUK City of London Centre's vision is to be at the forefront of cancer biotherapeutics in the UK and internationally, providing leadership for the wider CRUK Centres network.

Partners have contributed significantly to the field of intra-tumour heterogeneity and cancer evolution, elaborating its clinical significance and the unique challenges it poses for therapy of a dynamic tumour and its microenvironment. The CRUK City of London Centre will develop innovative biological therapies and diagnostics/stratification strategies working from an evolutionary and immunological perspective. The City of London Centre will explore the interplay between biological and other precision therapies to develop novel, potent and selective therapeutic combination approaches.

The unique research focus of the CRUK City of London Centre is predicated on the view that precision cancer therapy of the future will rely on the utilisation of biological therapies combined or in sequence with targeted small molecule approaches and new classes of spatially targeted and image-guided physical therapies.