"It is a privilege once again to introduce the Annual Review of the UCL Queen Square Institute of Neurology – a year that has been defined by outstanding translational progress, innovative partnerships and inspiring dedication across our community of researchers, clinicians, students and professional services staff."
"This year, our collective efforts have delivered remarkable advances in bringing neuroscience from bench to bedside. Among the highlights are pioneering blood tests and faster brain imaging techniques for Alzheimer’s disease – innovations that promise to transform early diagnosis and monitoring. We have also witnessed significant breakthroughs in clinical trials for Huntington’s disease, bringing new hope for patients and families affected by devastating neurodegenerative conditions. These successes exemplify our enduring commitment to translating world-leading discovery science into meaningful impact for individuals worldwide.
Our collaborations across UCL, UCLH and the UK Dementia Research Institute continue to strengthen the translational ecosystem that makes the institute unique. Through multidisciplinary teamwork, cutting-edge technology and a shared culture of excellence, we are shaping the future of neurological research and care.
This year has also been one of reflection and sadness, as we mark the passing of Professor Eleanor Maguire, whose pioneering work transformed our understanding of human memory and the brain’s remarkable capacity for spatial navigation. Eleanor was not only an exceptional scientist but also a deeply valued colleague, mentor and friend to many. Her intellectual legacy and humanity will continue to inspire generations of neuroscientists.
As we look ahead, we are preparing to celebrate two historic milestones: UCL’s bicentenary and the 75th anniversary of the UCL Queen Square Institute of Neurology, both to be commemorated in 2026. These occasions will offer an opportunity to honour our rich history and reaffirm our vision for the decades to come – one centred on curiosity, collaboration and the translation of discovery into tangible benefit for patients and society.
Our new site at 256 Grays Inn Road continues to take shape, symbolising our dual-hub model that brings together discovery neuroscience and clinical translation in a purpose-built environment. This new home will empower the next generation of neuroscientists to push the boundaries of knowledge and innovation.
Our academic excellence is only possible thanks to the dedication and professionalism of our professional services colleagues, whose expertise underpins everything we do – from education and research administration to operations, finance and technical support. Their contribution ensures the Institute runs smoothly and continues to thrive.
In reflecting on this year’s achievements and challenges, I am filled with pride and gratitude. The IoN community continues to demonstrate resilience, creativity and a shared purpose in tackling the most pressing neurological challenges of our time. I look forward to the year ahead with optimism and renewed energy as we continue to advance neuroscience for the benefit of all."
Professor Michael Hanna, Director, UCL Queen Square Institute of Neurology.
"It’s a privilege once again to present a selection of this year’s stories in our Annual Review, showcasing the breadth and impact of research at the IoN. It’s also been wonderful to see our scientists and their work so widely represented in the media, highlighting the strength and diversity of our community."
The Annual Review was launched at the Institute's Annual Address on 25th November 2025. It features interviews with the team at the Genetic Therapy Accelerator Centre (GTAC), the Neurogenetics Lab, Professor Ed Wild and a student testimonial from Michela Barioglio, Clinical Neuroscience: Neuromuscular Disease MSc.
The Review also highlights success in 2025 senior and early career promotions, and the year's activities at the Grays Inn Road site, including the Public Art programme. These achievements are complimented by reports on ION-wide EDI and Sustainability initiatives, Translation and Enterprise, and Educational activities
The Annual Review was produced in collaboration with Design Science and is available as an interactive document containing text, images and videos.