Image
This confocal image depicts neurodegeneration in the retina of an aged zebrafish with a mutation in the c9orf72 gene. Natalia Jaroszynska, a PhD student in the MacDonald laboratory, and colleagues explored the consequences of this mutation in vivo, as it is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Cell nuclei (blue) and rod (green) and cone photoreceptors (magenta) are labelled by immunofluorescence. This technique revealed that mutant zebrafish have a reduction of both photoreceptor types and a mislocalisation of rhodopsin from outer segments to cell bodies and synaptic terminals, indicating photoreceptor outer segment pathology.
The study on c9orf72-deficient zebrafish by Jaroszynska et al. is linked below.
The Journal of Neuroscience is an official journal of the Society for Neuroscience (SfN), seeking to advance neuroscience research by publishing and widely disseminating high-quality research representative of the breadth of neuroscience, ensuring transparent and fair peer review, and providing outlets for open discussion and debate that are not available elsewhere.
Links
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