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Amanda Davis and Mr Gus GazzardGlaucoma Service, Moorfields Eye Hospital, London, UK (2013). Co-ordinating a large pragmatic clinical trial- the role of the Ophthalmic CRF in facilitating trial management: Abstract and Poster acceptance at the UKCRN conference in Birmingham
Neil Nathwani, Amanda Davis, Evgenia Konstantakopoulou, Gus Gazzard Glaucoma Service, Moorfields Eye Hospital, London, UK (2015) "Reasons for non-participation in a randomised controlled trial and the effect of audiovisual material." Abstract and Poster acceptance to the 3rd International Clinical Trials Methodology Conference, Glasgow
Journals
Gazzard, G. et al. (2014). LiGHT: Health-Related Quality of Life in two treatment pathways for primary open angle glaucoma and ocular hypertension: a randomised controlled trial of initial selective laser trabeculoplasty versus conventional medical therapy. The Lancet.
Victoria Vickerstaff, Gareth Ambler, Catey Bunce, Wen Xing, Gus Gazzard and on behalf of the LiGHT study group: Statistical analysis plan for the Laser-1st vs Drops-1st for Glaucoma and Ocular Hypertension Trial (LiGHT): a multi-centre randomised controlled trial. Trials Journal. http://www.trialsjournal.com/content/16/1/517
Main report of the trial to the funder (NIHR HTA)
Selective laser trabeculoplasty versus drops for newly diagnosed ocular hypertension and glaucoma: the LiGHT RCT. Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K, Rubin G, Morris S, Buszewicz M.Health Technol Assess. 2019 Jun;23(31):1-102 See full article
Main results paper
Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial. Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K, Rubin G, Buszewicz M; LiGHT Trial Study Group. Lancet. 2019 Apr 13;393(10180):1505-1516 See full article
Clinical outcomes of SLT
Primary Selective Laser Trabeculoplasty for Open-Angle Glaucoma and Ocular Hypertension: Clinical Outcomes, Predictors of Success, and Safety from the Laser in Glaucoma and Ocular Hypertension Trial. Garg A, Vickerstaff V, Nathwani N, Garway-Heath D, Konstantakopoulou E, Ambler G, Bunce C, Wormald R, Barton K, Gazzard G; Laser in Glaucoma and Ocular Hypertension Trial Study Group. Ophthalmology. 2019 Sep;126(9):1238-1248 See full article
Baseline patient characteristics, trial design & statistical analysis plan
The Laser in Glaucoma and Ocular Hypertension (LiGHT) trial. A multicentre randomised controlled trial: baseline patient characteristics. Konstantakopoulou E, Gazzard G, Vickerstaff V, Jiang Y, Nathwani N, Hunter R, Ambler G, Bunce C; LiGHT Trial Study Group. Br J Ophthalmol. 2018 May;102(5):599-603 See full article
Laser in Glaucoma and Ocular Hypertension (LiGHT) trial. A multicentre, randomised controlled trial: design and methodology. Gazzard G, Konstantakopoulou E, Garway-Heath D, Barton K, Wormald R, Morris S, Hunter R, Rubin G, Buszewicz M, Ambler G, Bunce C; LiGHT Trial Study Group. Br J Ophthalmol. 2018 May;102(5):593-598 See full article
Statistical analysis plan for the Laser-1st versus Drops-1st for Glaucoma and Ocular Hypertension Trial (LiGHT): a multi-centre randomised controlled trial. Vickerstaff V, Ambler G, Bunce C, Xing W, Gazzard G; LiGHT Trial Study Group. Trials. 2015 Nov 11;16:517 See full article
