The Sleigh Lab works to understand mechanisms underlying hereditary peripheral nerve conditions, such as Charcot-Marie-Tooth disease (CMT), amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Established in 2019, we are part of the Department of Neuromuscular Diseases and based on the 5th floor of Queen Square House. Our research is currently principally funded by the Medical Research Council UK.
We are fascinated by how mutations in widely expressed genes can cause selective peripheral nerve pathology. We believe that by improving our understanding of the molecular and cellular mechanisms underpinning this phenomenon, we will be able to develop novel, targeted therapies for these devastating diseases.
Sleigh Lab
The Sleigh Lab works to understand mechanisms underlying hereditary peripheral nerve conditions, such as Charcot-Marie-Tooth disease (CMT), amyotrophic lateral sclerosis (ALS) and spinal muscular atro
Join us
We are always looking for enthusiastic and motivated scientists wishing to combine live imaging with comparative anatomical techniques to understand the peripheral nervous system. Positions are advertised through appropriate channels when they become available. There is also the possibility to create opportunities, so do please contact us, if you are interested: j.sleigh@ucl.ac.uk
Contact us
Dr James Sleigh
Principal Investigator
j.sleigh@ucl.ac.uk
Room 513, 5th Floor
Queen Square House
Queen Square
London WC1N 3BG
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Past and Present Funders
- The Medical Research Council UK
- The Rosetrees Trust
- The Wellcome Trust
- Muscular Dystrophy UK (MDUK)
- Neurogenetic Therapies Programme (UCL)