Professor Tammaryn Lashley's Group

Professor Tammaryn Lashley is a Professor of Neuroscience within the Department of Neurodegenerative Disease at UCL Queen Square Institute of Neurology. 

• ORCID: 0000-0001-7389-0348

Our research

Professor Tammaryn Lashley’s research focuses on the neuropathological, biochemical, and molecular characterisation of neurodegenerative diseases using human post-mortem tissue and translational experimental approaches. The Lashley Lab investigates the pathogenic mechanisms underlying frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, Parkinson’s disease, and related neurodegenerative disorders. A major focus of the group is understanding how distinct molecular and cellular mechanisms contribute to disease heterogeneity across pathological subtypes, with particular interest in protein mislocalisation, RNA-binding proteins, neurovascular dysfunction, and mechanisms associated with neuroinflammation and cellular stress responses.

The laboratory combines detailed human neuropathology with biochemical, molecular biological, and digital pathology methodologies to interrogate disease mechanisms in clinically and pathologically characterised cohorts. Current projects include investigations into hnRNP protein dysfunction in FTD and ALS, the role of human endogenous retroviruses (HERVs) in neurodegeneration, and studies examining vascular and endothelial dysfunction in neurodegenerative disease progression. The group also has expertise in the pathological assessment of familial and sporadic Alzheimer’s disease and Parkinson’s disease, including the study of selective neuronal vulnerability and glial pathology.

The Lashley Lab has established extensive national and international collaborations spanning neuropathology, neuroscience, biochemistry, cell biology, and clinical neurology. Collaborative partners include researchers within the University College London, the UK Dementia Research Institute, the University of Gothenburg, New York University, the University of Munich, and the University of Zurich. The research programme is highly interdisciplinary, integrating human tissue pathology with experimental cellular and molecular approaches to better understand disease mechanisms and identify potential therapeutic targets.

Alongside its research activity, the laboratory is strongly committed to training and mentorship. The group has expanded significantly through successful grant funding and has supported the development of research technicians, PhD students, MSc students, and post-doctoral researchers. Several former research staff have progressed to doctoral training in neuroscience, while current post-doctoral researchers are developing independent research portfolios and fellowship applications. The laboratory fosters a collaborative and supportive research culture, with regular team meetings dedicated to project development, manuscript preparation, grant applications, conference presentations, and career progression.

Selected publications

• Arber C, Casey JM, Crawford S, Rambarack N, Yaman U, Wiethoff S, Augustin E, Piers TM, Price M, Rostagno A, Ghiso J, Lewis PA, Revesz T, Hardy J, Pocock JM, Houlden H, Schott JM, Salih DA, Lashley T, Wray S.Acta Neuropathol. 2024 Nov 15;148(1):65. doi: 10.1007/s00401-024-02820-z. PMID: 39546024 Free PMC article.
• Abdi Z, Yong KX, Schott JM, Gatt A, Revesz T, Crutch SJ, Lashley T. Neuropathol Appl Neurobiol. 2025 Apr;51(2):e70007. doi: 10.1111/nan.70007. PMID: 40174910 Free PMC article.
• Feringa FM, Koppes-den Hertog SJ, Wang LY, Derks RJE, Kruijff I, Erlebach L, Heijneman J, Miramontes R, Pömpner N, Blomberg N, Olivier-Jimenez D, Johansen LE, Cammack AJ, Giblin A, Toomey CE, Rose IVL, Yuan H, Ward ME, Isaacs AM, Kampmann M, Kronenberg-Versteeg D, Lashley T, Thompson LM, Ori A, Mohammed Y, Giera M, van der Kant R.Nat Metab. 2025 Oct;7(10):2142-2164. doi: 10.1038/s42255-025-01365-z. Epub 2025 Sep 22.PMID: 40983680 Free PMC article.
• Simonetti F, Zhong W, Hutten S, Uliana F, Schifferer M, Rezaei A, Ramirez LM, Hochmair J, Sankar R, Gopalan A, Kielisch F, Riemenschneider H, Ruf V, Schmidt C, Simons M, Zweckstetter M, Wegmann S, Lashley T, Polymenidou M, Edbauer D, Dormann D.EMBO J. 2025 Dec;44(24):7395-7433. doi: 10.1038/s44318-025-00590-2. Epub 2025 Oct 17. PMID: 41107545 Free PMC article.
• Stepanchuk AA, Joseph JT, Lashley T, Stys PK.Neurobiol Aging. 2026 May 1;165:51-59. doi: 10.1016/j.neurobiolaging.2026.04.009. Online ahead of print. PMID: 42107415

Members of the lab

• Dr Yazead Buhidma
• Dr Barbara Frias Garrido
• Dr Ariana Gatt
• Ms Xinwa Jiang
• Miss Shubha Kamath
• Dr Christina Toomey