Translational Neuroscience and Stroke
Current trials in the Department.
| Short Title | Full Title | PI | Phase | Type |
|---|---|---|---|---|
| INSPIRES-2 | Improving sleep and learning in rehabilitation after stroke, part 2. | Ajina, Sara | Not Applicable | Non-commercial non-portfolio |
| ECST 2: The 2nd European Carotid Surgery Trial | ECST 2: The 2nd European Carotid Surgery Trial | Brown, Prof Martin | Not Applicable | Non-commercial portfolio |
| CONVINCE - Protocol Version 2.1 29th November 2016 | CONVINCE - COLchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke. | Chandratheva, Dr Arvind | Phase III | Non-commercial portfolio |
| Protocol 18-513 Andexanet ICH | A PHASE 4 RANDOMIZED CLINICAL TRIAL OF ANDEXANET ALFA [ANDEXANET ALFA FOR INJECTION] IN ACUTE INTRACRANIAL HEMORRHAGE IN PATIENTS RECEIVING AN ORAL FACTOR XA INHIBITOR | Chandratheva, Dr Arvind | Phase IV | Commercial portfolio |
| Mechanisms underlying spoken language production | Mechanisms underlying spoken language production: facilitating frontal brain networks following aphasic stroke | Crinion, Dr Jenny | Not Applicable | Non-commercial non-portfolio |
| Natural history and biomarkers in autonomic disorders | Natural history and biomarkers in autonomic disorders | Iodice, Dr Valeria | Not Applicable | Non-commercial non-portfolio |
| ATTEND | ATTEND: Attentional Therapy for the TrEatment of Neglect Disorder (ATTEND). | Leff, Prof Alexander | Not Applicable | Non-commercial portfolio |
| PLORAS version 1 | Predicting Language Outcome and Recovery After Stroke | Leff, Prof Alexander | Not Applicable | Non-commercial portfolio |
| Neural correlates of visual consciousness | The neural correlates of conscious visual experience in normal and brain damaged human subjects | Leff, Prof Alexander | Not Applicable | Non-commercial non-portfolio |
| Digital Interventions in Neuro-Rehabilitation (DINR) | Digital Interventions in Neuro-Rehabilitation: Two digital neuro interventions (DNIs)for word retrieval. The development and testing of two web-based therapy applications for people with naming difficulties caused by Stroke (iTALKbetter) or Mild-Moderate Dementia (Gotcha!) | Leff, Prof Alexander | Study | Non-commercial non-portfolio |
| BPL-PSILO | An Exploratory Open-Label, Phase 1b, Ascending Dose Study to Evaluate the Effects of Oral 3 [2 (dimethylamino)ethyl]-1h-indol-4-yl (Psilocybin, BPL PSILO) on Cognition in Patients With Chronic Short-Lasting Unilateral Neuralgiform Headache Attacks (SUNHA) | Matharu, Dr Manjit | Phase Ib | Commercial portfolio |
| Headache and facial pain: a prospective clinical study | Primary and secondary headaches and facial pain disorders: a prospective clinical study | Matharu, Dr Manjit | Not Applicable | Non-commercial non-portfolio |
| BASIC Study | BASIC - Botulinum toxin type A blockade of the sphenopalatine ganglion in treatment-refractory chronic cluster headache | Matharu, Dr Manjit | Phase III | Non-commercial portfolio |
| Craniocervical imaging in joint hypermobility disorders (version 1) | Headache disorders and imaging of the craniocervical junction in joint hypermobility disorders | Matharu, Dr Manjit | Not Applicable | Non-commercial portfolio |
| Cytokines in chronic headache disorders | Cytokines and inflammatory biomarkers in chronic headache and facial pain disorders | Matharu, Dr Manjit | Not Applicable | Non-commercial non-portfolio |
| Lesion Function Mapping | High-Dimensional Lesion-Function Mapping of the Human Brain | Nachev, Dr Parashkev | Study | Non-commercial non-portfolio |
| Neurophysiology evaluation of symptomatic sacral Tarlov cysts | A comprehensive evaluation of the effects of sacral Tarlov cysts on pelvic organ functions and neurophysiological parameters of the pelvic floor | Panicker, Dr Jalesh | Not Applicable | Non-commercial non-portfolio |
| MultiStem® Administration for Stroke Treatment and Enhanced Recovery | MultiStem® Administration for Stroke Treatment and Enhanced Recovery Study (MASTERS-2) | Perry, Dr Richard | Phase III | Commercial portfolio |
| Study Exploring The Impact of COVID-19 On Stroke (SETICOS) | Study Exploring The Impact of COVID-19 On Stroke (SETICOS) | Perry, Dr Richard | Not Applicable | Non-commercial portfolio |
| ATTEST 2 | Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST 2) | Perry, Dr Richard | Phase III | Non-commercial portfolio |
| Validation Of Bioarray In Stroke | Validation Of Bioarray In Stroke (VOBIS). | Perry, Dr Richard | Not Applicable | Commercial portfolio |
| Mechanisms underlying limb apraxia | Understanding motor processing pathways to guide therapy for limb apraxia | Perry, Dr Richard | Not Applicable | Non-commercial portfolio |
| 252LH301: Efficacy & Safety of IV BIIB093 (The CHARM Study) | Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction | Perry, Dr Richard | Phase III | Commercial portfolio |
| PERCIVAL | Periodontitis, COVID-19 and Cerebrovascular Disease | Simister, Dr Robert | Not Applicable | Non-commercial portfolio |
| Prehospital triage for stroke patients (PHOTONIC) (v1.0) | PreHOspital Triage for potential stroke patients: lessONs from systems Implemented in response to COVID19 (PHOTONIC) | Simister, Dr Robert | Not Applicable | Non-commercial portfolio |
| TEMPO-2 | Multicentre, prospective randomized open label, blinded-endpoint (PROBE) controlled trial of thrombolysis with low dose Tenecteplase (TNK-tPA) versus standard of care in the prevention of disability at 3 months in minor ischemic stroke with proven acute symptomatic occlusion | Simister, Dr Robert | Phase III | Non-commercial portfolio |
| prophylaxis of post-stroke epilepsy | prevention of epilepsy in stroke patients at high risk of developing unprovoked seizures: anti-epileptogenic effects of eslicarbazepine acetate | Simister, Dr Robert | Phase II | Commercial portfolio |
| Biomarkers of early stroke recovery (BEST) study. Version 2. | Biomarkers of early stroke recovery (BEST) | Ward, Prof Nick | Not Applicable | Non-commercial portfolio |
| INTENSIVE | Is intensive upper limb rehabilitation effective in chronic stroke patients? A randomised controlled trial | Ward, Prof Nick | Not Applicable | Non-commercial portfolio |
| TRACS study | Tracking Reticulospinal And Corticospinal pathways after Stroke TRACS study | Ward, Prof Nick | Not Applicable | Non-commercial non-portfolio |
| tDCS in post-stroke fatigue (TIPS) | Does diminished motor cortical excitability cause post-stroke fatigue? | Ward, Prof Nick | Not Applicable | Non-commercial portfolio |
| MOtor Control After Stroke (MOCAS) | Does the upper limb rehabilitation programme lead to a general improvement in motor control processes in chronic stroke patients? | Ward, Prof Nick | Not Applicable | Academic/student |
| STROKE ODYSSEYS Version 1 | Evaluation of an interdisciplinary performance arts intervention that combines movement and voice to reduce anxiety and depression among those living with the effects of a stroke. | Ward, Prof Nick | Not Applicable | Non-commercial non-portfolio |
| Re-opening the Critical Period after Stroke (ReCAPS). Version 1.0 | Re-opening the critical period for plasticity after stroke with dose-controlled non-invasive brain stimulation | Ward, Prof Nick | Not Applicable | Non-commercial portfolio |
| TICH-3 | Tranexamic acid for Hyperacute Spontaneous Intracerebral Haemorrhage (TICH-3) | Werring, Dr David | Phase III | Non-commercial portfolio |
| ENRICH-AF: Edoxaban for IntraCranial Haemorrhage survivors with AF | EdoxabaN foR IntraCranial Haemorrhage survivors with atrial fibrillation (ENRICH-AF) | Werring, Dr David | Phase III | Non-commercial portfolio |
| PROHIBIT-ICH | Prevention Of Hypertensive Injury to the Brain by Intensive Treatment after Intracerebral Haemorrhage: a pilot randomised trial of home telemetry-guided treatment | Werring, Dr David | Not Applicable | Non-commercial portfolio |
| Genetic risk factors for cerebral small vessel disease | Genetic risk factors for cerebral small vessel disease | Werring, Dr David | Not Applicable | Non-commercial portfolio |
| Familial Cerebral Small Vessel Disease | A UK Familial Cerebral Small Vessel Disease Study | Werring, Dr David | Not Applicable | Non-commercial portfolio |
| Tenecteplase in Wake-up Ischaemic Stroke Trial | Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST) | Werring, Dr David | Phase III | Non-commercial portfolio |
| Prediction of stroke outcome using brain imaging machine-learning | Optimizing prediction of stroke outcome using brain imaging machine-learning | Werring, Dr David | Not Applicable | Non-commercial portfolio |
| OPTIMAS Trial | OPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trial (OPTIMAS Trial) | Werring, Dr David | Not Applicable | Non-commercial portfolio |
| R4VaD | Rates, Risks and Routes to Reduce Vascular Dementia (R4VaD) | Werring, Dr David | Not Applicable | Non-commercial portfolio |