Research Department of Epilepsy
Current trials in the Department.
| Title | PI | Phase | Type |
|---|---|---|---|
| Memory in patients with epilepsy: an intracranial electroencephalography multiplecase study at the National Hospital for Neurology and Neurosurgery | Dr Beate Diehl | Not Applicable | Non-commercial non-portfolio |
| Retrospective SUDEP at Epilepsy Centers: A Case-Control Study | Dr Beate Diehl | Not Applicable | Non-commercial portfolio |
| Optimising cognitive outcomes in epilepsy surgery with direct cortical stimulation: a pilot, feasibility study | Dr Beate Diehl | Not Applicable | Non-commercial non-portfolio |
| The Prevention and Risk Identification of SUDEP (Sudden Unexpected Death in Epilepsy) Mortality - PRISM Project | Dr Beate Diehl | Not Applicable | Non-commercial non-portfolio |
| A Transcranial Magnetic Stimulation study to measure cortical excitability in people with epilepsy | Dr Fahmida Chowdhury | Not Applicable | Non-commercial portfolio |
| Evaluation and optimization of a wearable technology for detection of body sounds related to apnoea in epilepsy. | Dr Fergus Rugg-Gunn | Not Applicable | Non-commercial non-portfolio |
| Interoceptive processing and training on cardiac symptoms and anxiety (CARDIA) | Dr Mahinda Yogarajah | Not Applicable | Non-commercial non-portfolio |
| Aligning Dimensions of Interoceptive Experience in Functional Seizures: A Feasibility Pilot Study | Dr Mahinda Yogarajah | Not Applicable | Non-commercial non-portfolio |
| Epilepsy (surgical and post mortem) research tissue bank. | Dr Maria Thom | Not Applicable | Non-commercial non-portfolio |
| Longitudinal cognitive fMRI: Rehabilitation and Surgery in epilepsy | Dr Meneka Sidhu | Not Applicable | Non-commercial non-portfolio |
| CANnabidiol impact on challenging behaviour in Adults with Intellectual Disability with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complex (CANABID-LD): a prospective observational cohort study. | Dr Meneka Sidhu | Not Applicable | Non-commercial portfolio |
| Interoception and Sense of Agency in Individuals with Functional Seizures | Dr Rohan Kandasamy | Not Applicable | Non-commercial portfolio |
| A post-market, long-term, prospective, observational, multi-site outcome study to follow the clinical course and seizure reduction of patients with refractory seizures who are being treated with adjunctive VNS Therapy | Mr Andrew McEvoy | Not Applicable | Commercial portfolio |
| Optimizing epilepsy surgery | Prof John Duncan | Not Applicable | Non-commercial portfolio |
| The 7-Tesla Temporal Lobe Epilepsy Study | Prof John Duncan | Not Applicable | Non-commercial non-portfolio |
| Multicentre Epilepsy Lesion Detection Project: a collaborative cohort for the analysis of focal epilepsies | Prof John Duncan | Not Applicable | Non-commercial non-portfolio |
| Evaluation of Artificial Intelligence-enhanced Low Field Magnetic Resonance Imaging in Epilepsy | Prof John Duncan | Not Applicable | |
| High frequency oscillations in epilepsy patients: an intracranial electroencephalography and single unit recording multicase study at the National Hospital for Neurology and Neurosurgery | Prof Matthew Walker | Not Applicable | Non-commercial non-portfolio |
| The use of portable Magnetoencephalography (MEG) in epilepsy. v1.1 | Prof Matthew Walker | Not Applicable | Non-commercial non-portfolio |
| Volatile non-Invasive Biomarkers of Epileptic Seizures | Prof Matthew Walker | Not Applicable | Non-commercial portfolio |
| Pilot Pharmacological fMRI Study - The effects of drugs on cognition in epilepsy | Prof Matthias Koepp | Not Applicable | Non-commercial non-portfolio |
| Epiphany: Epilepsy and neurodegeneration: disease mechanisms and early detection | Prof Matthias Koepp | Not Applicable | Non-commercial non-portfolio |
| FMRI study of cognition in patients with idiopathic epilepsies and their siblings | Prof Matthias Koepp | Not Applicable | Non-commercial non-portfolio |
| A Randomized, Double-blind, Placebo-controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Focal-onset Epilepsy | Prof Matthias Koepp | Phase III | Commercial portfolio |
| A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures | Prof Matthias Koepp | Phase III | Commercial portfolio |
| Multicenter, Open-label, Long-term, Safety, Tolerability, and Efficacy Study of XEN1101 in Adults Diagnosed With Epilepsy | Prof Matthias Koepp | Phase III | Commercial portfolio |
| A Phase 2/3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy, Safety and Tolerability of BHV-7000 in Subjects with Refractory Focal Onset Epilepsy (RISE-3) | Prof Matthias Koepp | Phase III | Commercial portfolio |
| A Phase 2, Global, Multicenter, Long-term Safety Study Designed to Assess the Safety and Tolerability of BHV-7000 in Subjects with Refractory Focal Onset Epilepsy | Prof Matthias Koepp | Phase II | Commercial portfolio |
| Epilepsy Pharmacogenomics: delivering biomarkers for clinical use | Prof Sanjay Sisodiya | Not Applicable | Non-commercial portfolio |
| Cortical excitability in subjects with genetic neurological disorders, a Transcranial Magnetic Stimulation study | Prof Sanjay Sisodiya | Not Applicable | Academic/student |
| SCN1A Horizons: A natural history study of SCN1A-related epilepsies in the United Kingdom | Prof Sanjay Sisodiya | Not Applicable | Non-commercial portfolio |
| Non-invasive Monitoring of Antiepileptic Drug Levels – A Pilot Study | Prof Sanjay Sisodiya | Not Applicable | Non-commercial portfolio |
| Dissecting mTOR Pathway Mosaicism in FCDII-Harbouring Epileptic Brain and Peripheral Tissue. | Prof Sanjay Sisodiya | Not Applicable | Non-commercial portfolio |
| A study of in-ear electroencephalography signals additionally recorded in hospitalised patients already undergoing standard clinical electroencephalography | Dr Umesh Vivekananda | Not Applicable | Non-commercial non-portfolio |
| Epilepsy imaging with 11C-PBR28 PET: assessment of variability | Prof Matthew Walker | Not Applicable | Non-commercial portfolio |