Division of Neuropathology
The Division of Neuropathology at Queen Square is a leading academic and diagnostic neuropathology department in the UK.
The Division of Neuropathology at Queen Square is a leading academic and diagnostic neuropathology department in the UK. The department provides services for the National Hospital of Neurology and Neurosurgery, University College London Hospital, and receives a substantial number of national referrals.
Popular downloads:
Immunostaining request form for external users
Molecular pathology request form
Members of the Division of Neuropathology
Members of the Division.
Molecular Pathology
We offer DNA methylation profiling for advanced diagnostics and prognostication of brain tumours.
Adult Neuromuscular Service
We provide a diagnostic service and support the mitochondrial disease and the McArdle’s disease NCG services.
Dubowitz Neuromuscular Centre
Specialised in neuromuscular disorders affecting children and young adults. We provide the diagnostic neuropathology for Congenital Muscular Dystrophies and Congenital Myopathies
Brain autopsies
We perform autopsies on brains including high risk (prion diseases, Creutzfeldt-Jakob disease).
UCL IQPath
Research histology facility, digital pathology and image analysis on the highest technical level.
Access to tissue resources for research
We can make our archival diagnostic tissue samples available to researchers.
Electron microscopy
Comprehensive facilities for specimen preparation and access to Transmission Electron Microscopes at Great Ormond Street Hospitals.
Clinical Trial support
We support numerous clinical trials, by providing tissue or molecular data, and we can provide input to the pathology workflow in clinical trial design.
Please contact UCLH.trials.neuropathology@nhs.net to get in touch and to request tissue. Please be advised that we do not run clinical trials and we cannot advise on the eligibility and suitability of patients for clinical trials.
Prof. Sebastian Brandner, in collaboration with Department of Neurodegenerative Disease and MRC Prion Unit
The principal focus of the MRC Prion Unit is on the human prion disease, and the research strategy is aimed at both rapid developments to target these areas of public health concern and a long term approach to the understanding of prion disease and the wider relevance of prion-like molecular mechanisms in pathobiology
Dr Maria Thom is affiliated with the Department of Clinical and Experimental Epilepsy
In the recent years we have focused studies on specific pathologies including hippocampal sclerosis. In our post mortem series we have, using stereological analysis, examined the distribution of cell loss along the longitudinal axis, noting variability of the pattern in relation to patients seizures. We have been examining the differences in patterns of interneuronal loss in the hippocampus in relation to seizures. We have published studies on the severity of Alzheimer-type pathology in a large post-mortem series of patients with epilepsy and correlated accelerated aging with evidence of old traumatic brain injury incurred as a result of seizures. We are also studying the contribution of immature and progenitor cells types, including doublecortin, NG2 and nestin-positive neurones in the pathology focal cortical dysplasia (FCD). We have recently explored the mechanisms of altered patterns of myelination observed in FCD. We have studied the immunophenotype and molecular-genetic characteristics of subtypes of long-term epilepsy-associated tumours (LEATs). In sudden and unexpected death in epilepsy (SUDEP) we have been identifying the distribution of acute neuronal injury through neuronal expression of HIF1 alpha and VEGF.