PhD Opportunity in Mitochondrial Dysfunction and Neurodegeneration

• Location: UCL Queen Square Institute of Neurology, Department of Clinical and Movement Neurosciences, London, UK
  Supervisors: Prof Antonella Spinazzola (Primary), Dr Matthew Gegg, Dr Ian James Holt
  Funding: My Mitomission, Full-time, fully funded PhD position
  Start Date: September 2025 
  Application Deadline: 23:59 GMT, 22 June 2025

Project Overview

This exciting PhD opportunity is embedded within a world-leading environment for neurological research. The student will explore novel mechanisms linking mitochondrial dysfunction and neurodegeneration, recently uncovered by the host research group.
Key research aims include:
•    Investigating the impact of mitochondrial dysfunction on ⍺-synuclein, the hallmark protein in Parkinson’s disease pathology.
•    Testing targeted interventions using both in vitro and in vivo models of genetic mitochondrial disorders and Parkinson’s disease.
This project offers rich multidisciplinary training in mitochondrial biology, molecular neuroscience, and translational research, and will contribute to a rapidly evolving field with direct clinical implications.

Person Specification

Essential Criteria:
•    MD or Bachelor's degree (2:1 or higher) in a relevant subject (e.g. Neuroscience, Molecular Biology).
•    Ability to work within multidisciplinary, collaborative environments.
•    Some prior experience in data processing and analysis.
•    Strong written and oral communication skills, with enthusiasm to learn academic writing and presentation delivery.
Desirable Criteria:
•    Master’s degree in a related discipline.

How to Apply

Please submit your application to Prof Antonella Spinazzola at a.spinazzola@ucl.ac.uk with the subject line: PhD Application – Mitochondria & Neurodegeneration.
Your application should include:
1.    Curriculum Vitae (max 2 pages)
2.    Personal Statement (max 600 words) addressing: i) Why you are applying for this specific project. ii) What makes you an ideal candidate. Iii) A summary of your relevant training and experience.
3.    Referee Contact: Provide the name and contact information for at least one academic referee.

This is a unique opportunity to join a dynamic team working at the intersection of mitochondrial disease and neurodegenerative research, with mentoring from internationally recognised experts. The project offers an excellent platform for launching a research career in translational neuroscience.

The position is funded for UK and EU students; the exact amount may vary depending on your nationality and fee status. Non-EU applicants are welcome to apply but must secure alternative funding to cover international tuition fees. The project includes a tax-free stipend of £21,000 per year for 4 years to support living costs. 

Only shortlisted candidates for interviewed will be notified. For further information contact Prof Antonella Spinazzola, a.spinazzola@ucl.ac.uk