IoO Seminar Series with Birgit Lorenz
Title: Challenges to quantify peripheral retinal changes in inherited retinal diseases and following subretinal gene therapy as novel biomarkers.
IoO Seminar Series with Birgit Lorenz
Birgit Lorenz
Challenges to quantify peripheral retinal changes in inherited retinal diseases and following subretinal gene therapy as novel biomarkers
TransMIT Centre of Translational Ophthalmology c/o Justus-Liebig-University Giessen, Germany
Subretinal gene augmentation therapy has shown significant success to treat autosomal recessive RPE65-related inherited retinal diseases (IRDs). However, adverse effects include peripheral chorioretinal atrophies independent of age such as gene therapy associated uveitis (GTAU). Therefore, differentiation of treatment-related effects from natural disease progression is highly warranted.