Brain Meeting: Tricia Seow

Tricia Seow (Senior Research Fellow, Max-Planck UCL Centre for Computational Psychiatry and Ageing Research)

Please contact ion.fil.brainmeetings@ucl.ac.uk for a Zoom link.

Abstract: Compulsions and obsessions are core symptoms of obsessive-compulsive disorder (OCD). In this talk, I will focus on two mental processes that contribute to these symptoms: biases in belief and biases in mental simulation. First, I will discuss metacognitive biases—explicit confidence ratings—showing that overconfidence in decisions is linked to a transdiagnostic dimension of compulsivity, replicated across multiple cognitive domains. The rigidity of this overconfidence appears to arise from an impaired sensitivity to external feedback signals. Next, I will turn to the period preceding explicit belief reports—deliberation—and examine mental simulation, measured using magnetoencephalography (MEG) to track neural replay during decision-making. I will show that humans use replay to simulate options before decisions, and that in OCD, individuals with higher obsessional symptoms show exaggerated replay for salient outcomes, which is associated with increased avoidance behaviour. Together, these findings suggest that biases in implicit simulation and explicit belief may represent complementary mechanisms, contributing to obsessional and compulsive symptoms, respectively. I will close with a hierarchical framework that extends to broader forms of self-reflection in the clinic and offers a step toward a unified conceptualisation of metacognition across neurocognitive and clinical disciplines.