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There are many lines of evidence to suggest that a proportion of psychosis has an autoimmune basis however to date there have not been any biomarkers to guide diagnosis or treatment. This has potentially changed with the discovery of neuronal cell surface antibodies: They are considered pathogenic in patients with limbic encephalitis, often presenting with prominent psychiatric symptoms. The relevance of the same antibodies in patients with purely psychiatric presentations is now evolving. I will discuss the current evidence around autoimmune psychosis, and implications for clinical practice.
