UCL Division of Biosciences


Selected Publications

Lezmy J, Arancibia-Cárcamo IL, Quintela-López T, Sherman DL, Brophy PJ, Attwell D. (2021) Astrocyte Ca2+ -evoked ATP release regulates myelinated axon excitability and conduction speed. Science 374, eabh2858. DOI: 10.1126/science.abh2858.

Nortley R, Korte N, Izquierdo P, Hirunpattarasilp C, Mishra A, Jaunmuktane Z, Kyrargyri V, Pfeiffer T, Khennouf L, Madry C, Gong H, Richard-Loendt A, Huang W, Saito T, Saido TC, Brandner S, Sethi H, Attwell D. (2019) Amyloid oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes. Science 365, 250 DOI: 10.1126/science.aav9518.

Krasnow, A.M., Ford, M.C., Valdivia, L.E., Wilson, S.W. & Attwell, D. (2018)  Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nature Neurosci. 21, 24-28.

Jolly, S., Bazargani, N., Quiroga, A.C., Pringle, N.P., Attwell, D., Richardson, W.D. & Li, H. (2018)  G protein-coupled receptor 37-like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia. Glia 66, 47-61.

Madry, C., Kyrargyri, V., Arancibia-Cárcamo, I.L., Jolivet, R., Kohsaka, S., Bryan, R.M. & Attwell, D.  Microglial Ramification, Surveillance, and Interleukin-1 Release Are Regulated by the Two-Pore Domain K+ channel THIK-1. Neuron. 2018 Jan 17;97, 299-312.

O'Farrell, F.M., Mastitskaya, S., Hammond-Haley, M., Freitas, F., Wah, W.R. & Attwell, D. (2017)  Capillary pericytes mediate coronary no-reflow after myocardial ischaemia. Elife. 2017 Nov 9;6. pii: e29280. doi: 10.7554/eLife.29280.

Kougioumtzidou, E., Shimizu, T., Hamilton, N.B., Tohyama, K., Sprengel, R., Monyer, H., Attwell, D. & Richardson, W.D. (2017)  Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival.  Elife. 6, pii: e28080. Bazargani, N. & Attwell, D. (2017) Amines, Astrocytes, and Arousal. Neuron 94, 228-231.

Arancibia-Carcamo, I.L., Ford, M.C., Cossell, L., Ishida, K., Tohyama, K. & Attwell, D. (2017) Node of Ranvier length as a potential regulator of myelinated axon conduction speed. eLife e23329.

Mishra, A., Reynolds, J., Chen, Y., Gourine, A., Rusakov, D. & Attwell, D. (2016) Astrocytes mediate neurovascular signalling to capillary pericytes but not to arterioles. Nature Neuroscience 19, 1619-1627.

Hamilton, N.B., Kolodziejczyk, K., Kougioumtzidou, E. & Attwell, D. 2016) Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia. Nature 529, 523-527.

Bazargani, N. & Attwell, D. (2016) Astrocyte calcium signalling: the third wave. Nature Neuroscience 19, 182-189.

Attwell, D., Mishra, A., Hall, C., O'Farrell, F. & Dalkara, T. (2016) What is a pericyte? J. Cereb. Blood Flow Metab. 36, 451-455.

Hamilton, N.B., Clarke, L., Arancibia-Carcamo, I.L., & Attwell, D. (2016) Endogenous GABA release regulates oligodendrocyte precursor cell proliferation, myelination, and internode length, Glia 65, 309-321.

Harris, J.J., Jolivet, R., Engl, E. & Attwell, D. (2015) Energy-efficient information transfer by visual pathway synapses. Current Biology 25, 3151-3160.

Ford, M.C., Alexandrova, O., Cossell, L., Stange-Marten,, A., Sinclair, J., Kopp-Scheinpflug, C., Pecka, M., Attwell, D. & Grothe, B. (2015)Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing. Nature Commun. 6: 8073.

Hall, C.N., Reynell, C., Gesslein, B., Hamilton, N.B., Mishra, A., Sutherland, B., O'Farrell, F.M., Buchan, A.M., Lauritzen, M. & Attwell, D. (2014) Capillary pericytes regulate cerebral blood flow in health and disease. Nature 508, 55-60.

Arancibia-Carcamo, I.L. & Attwell, D. (2014) The node of Ranvier in CNS pathology. Acta Neuropathologica 128, 161-175.

O'Farrell, F.M. & Attwell, D. (2014) A role for pericytes in coronary no-reflow. Nat. Rev. Cardiol. 11, 427-432.

Lundgaard, I., Luzhynskaya, A., Stockley, J.H., Wang, Z., Evans, K.A., Swire, M., Volbracht, K., Gautier, H.O., Franklin, R.J., ffrench-Constant, C., Attwell D, Káradóttir RT. (2013) Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes. PLoS Biol. 11, e1001743.

Young, K.M., Psachoulia, K., Tripathi, R.B., Dunn, S.J., Cossell, L., Attwell, D., Tohyama, K. & Richardson, W.D. (2013) Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling. Neuron 77, 873-885.

Harris, J.J., Jolivet, R. & Attwell, D. (2012) Synaptic energy use and supply. Neuron 75, 762-777.

Harris, J.J. & Attwell, D. (2012) The energetics of central nervous system white matter. J. Neurosci. 2, 356-371.

Attwell, D., Buchan, A.M., Charpak, C., Lauritzen, M., MacVicar, B.A. & Newman, E.A. (2010) Glial and neuronal control of brain blood flow. Nature 468, 232-243. 

Hamilton, N.B. & Attwell, D. (2010) Do astrocytes really exocytose neurotransmitters? Nature Reviews Neuroscience 11, 227-238 

MacAskill, A.F., Rinholm, J.E., Twelvetrees, A.E., Arancibia-Carcamo, I.L., Muir, J., Fransson, A., Aspenstrom, P., Attwell, D. & Kittler, J. (2009) Miro1 is a calcium sensor for glutamate receptor dependent localization of mitochondria at synapses. Neuron 61, 541-555. News and views on this paper: http://www.cell.com/neuron/abstract/S0896-6273(09)00125-1

Káradóttir, R., Hamilton, N.B., Bakiri, Y. & Attwell, D. (2008) Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter. Nature Neuroscience 11, 450-456. News and views on this paper: http://www.nature.com/neuro/journal/v11/n4/abs/nn0408-379.html

Schölvinck, M., Howarth, C. & Attwell, D. (2008) The cortical energy use underlying conscious perception. Neuroimage 40, 1460-1468

Peppiatt, C.M., Howarth, C., Mobbs, P. & Attwell, D. (2006) Bidirectional control of CNS capillary diameter by pericytes Nature 443, 700-704. News and Views on this paper: http://www.nature.com/nature/journal/v443/n7112/full/443642a.html

Káradóttir, R. & Attwell, D. (2006) Combining patch-clamping of cells in brain slices with immunocytochemical labelling to define cell type and developmental stage. Nature Protocols 1, 1977-1986

Káradóttir, R., Cavelier, P., Bergersen L.H.& Attwell, D (2005) NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature 438, 1162-1169. 

Attwell, D. & Gibb, A (2005) Neuroenergetics and the kinetic design of excitatory synapses. Nature Reviews Neuroscience 6, 841-849.

Marcaggi, P. & Attwell, D. (2005) Endocannabinoid signalling depends on the spatial pattern of synapse activation. Nature Neuroscience 8, 776-781 

Allen,N.J., Rossi,D.J. & Attwell,D. (2004) Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischaemia of hippocampal slices. J. Neurosci. 24, 3837-3849. 

Marcaggi,P., Billups,D., Attwell,D. (2003) The role of glial glutamate transporters in maintaining the independent operation of juvenile mouse cerebellar parallel fibre synapses. J. Physiol. 552, 89-107.

Hamann,M., Rossi,D., Attwell,D. (2002) Tonic and spillover inhibition control information flow through cerebellar cortex. Neuron.33, 625-633. 

Attwell,D., Laughlin,S.B. (2001) An energy budget for signalling in the grey matter of the brain. J. Cereb. Blood Flow & Metab. 21, 1133-1145. 

Auger,C., Attwell,D. (2000) Fast removal of synaptic glutamate by postsynaptic transporters. Neuron 28, 547-558. 

Billups,D., Hanley,J.G., Orme,M., Attwell,D., Moss,S. (2000) GABAC receptor sensitivity is modulated by interaction with MAP1B. J. Neurosci. 20, 8643-8650. 

Rossi,D., Oshima,T., Attwell,D. (2000) Glutamate release in severe brain ischaemia is mainly by reversed uptake. Nature 403, 316-321.

Marie,H., Attwell,D. (1999) C-terminal interactions modulate the affinity of GLAST glutamate transporters in salamander retinal glial cells. J. Physiol. 520, 393-397. 

Levy,L.M., Warr,O., Attwell,D. (1998) Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake. J. Neurosci. 18, 9620-9628. 

Takahashi,M., Sarantis,M., Attwell,D. (1996) Postsynaptic glutamate uptake in rat cerebellar Purkinje neurons. J. Physiol. 497, 523-530.

Billups,B., Attwell,D. (1996) Modulation of non vesicular glutamate release by pH. Nature 379, 171 174.

Szatkowski,M., Attwell,D. (1994) Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms. Trends in Neurosci. 17, 359 365. 

Attwell,D., Barbour,B., Szatkowski,M. (1993) Nonvesicular release of neurotransmitter. Neuron 11, 401 407.

Sarantis,M., Ballerini,L., Miller,B., Silver,A., Edwards,M., Attwell,D. (1993) Glutamate uptake from the synaptic cleft does not shape the decay of the non NMDA component of the synaptic current. Neuron 11, 541 549. 

Bouvier,M., Szatkowski,M., Amato,A., Attwell, D. (1992) The glial cell glutamate uptake carrier counter transports pH changing anions. Nature 360, 471 474

Miller,B., Sarantis,M., Traynelis,S., Attwell, D. (1992) Potentiation of NMDA receptor currents by arachidonic acid. Nature 355, 722 725 

Szatkowski,M., Barbour,B., Attwell,D. (1990) Non vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature 348, 443 446 

Barbour,B., Szatkowski,M., Ingledew,N., Attwell,D. (1989) Arachidonic acid induces a prolonged block of glial cell glutamate uptake. Nature 342, 918 920 

Barbour,B., Brew,H., Attwell,D. (1988) Electrogenic glutamate uptake is activated by intracellular potassium Nature 335, 433 435

Sarantis,M., Everett,K., Attwell,D. (1988) A presynaptic action of glutamate at the cone output synapse. Nature 332, 451 453 

Attwell,D., Borges,S., Wu,S., Wilson,M. (1987) Signal clipping by the rod output synapse. Nature 328, 522 524

Brew,H., Attwell,D. (1987) Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells. Nature 327, 707 709 

Brew, H., Gray, P.T., Mobbs, P. & Attwell, D. (1986) Endfeet of retinal glial cells have higher densities of ion channels that mediate K+ buffering Nature 324, 466-468.