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UCL Division of Biosciences

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Dr Mie Wong

Dr Mie Wong

Sir Henry Dale Fellow

Cell & Developmental Biology

Div of Biosciences

Joined UCL
15th Sep 2021

Research summary

Our lab studies cell migration, how cells move from one place to another. This process is central to development, immune response and many diseases. An open question in the field is how migrating cells can robustly arrive at the desired final target through dynamically adapting to changes in the microenvironment. The developing zebrafish embryo is transparent and thus ideal for monitoring, in real time, the dynamic responses of moving cells to change. Interestingly, key molecular players in developmental cell migration are highly relevant to human diseases including cancer. 

We will dissect the molecular, cellular and tissue mechanisms that enable cells migrating in vivo to effectively sense and cope with change. This will be achieved by employing a multitude of techniques e.g. advanced time-lapse imaging, optogenetics, quantitative image analysis, phosphoproteomics and mathematical modeling. The goal of our research is to reveal common mechanisms in healthy and pathological cell migratory adaptation.

Work in our lab is generously supported by the Wellcome Trust and Royal Society.

Biography

2018-2020 | Postdoctoral Fellow, University of Zurich, Switzerland 

2015-2018 | Postdoctoral Fellow, EMBL Heidelberg, Germany

2010-2014 | PhD (MRC LMB), University of Cambridge, United Kingdom

2007-2010 | BA (Natural Sciences), University of Cambridge, United Kingdom

Publications