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Prof Jurg Bahler
Chair in Molecular Systems Biology
Genetics, Evolution & Environment
Div of Biosciences
- Joined UCL
- 1st Jun 2008
Research summary
The characteristics of organisms result largely from the dynamic interplay between DNA or RNA and the regulatory apparatus. The control of gene expression is fundamental to implement the information in the genome and to determine the properties of different organisms. Gene expression is regulated at multiple levels, and cells need to integrate external and internal cues and coordinate different regulatory levels to properly exert biological functions. We study transcriptional and post-transcriptional gene expression programmes during cellular proliferation, quiescence/ageing, and stress response using Schizosaccharomyces pombe as a model system. We apply multiple genetic and high-throughput approaches for systems-level understanding of regulatory networks and complex relationships between genotype, phenotype, and environment, including roles of genome variation and evolution, transcriptome regulation, and non-coding RNAs.
Recently, we have started to work with the turqouise killifish (Nothobranchius furzeri), a short-lived vertebrate model to study ageing and associated diseases.
Teaching summary
Undergraduate Courses:
BIOC0004 - Introduction to Microbiology BIOL1004
BIOC0030 - Advanced Molecular Biology of Protein Regulatory Networks
BIOL0025 - Advanced Molecular Biology: Genomics and Evolution
Graduate Courses:
Principles in Biology (BBSRC LIDo DTP)
CoMPLEX ABC
Education
- Universitat Bern
- Doctorate, Doctor of Philosophy | 1994
- Universitat Bern
- First Degree, Bachelor of Science | 1990
Biography
Jürg Bähler completed his PhD studies on meiotic chromosome metabolism at the University of Bern (Switzerland) under the supervision of Jürg Kohli. After short stays as a Research Associate in Japan and Switzerland, he worked as a Postdoctoral Fellow with John Pringle at the University of North Carolina (Chapel Hill, USA) and with Paul Nurse at the Imperial Cancer Research Fund (London, UK), studying cellular morphogenesis and cell-cycle regulation. In 2000, Bähler joined the Wellcome Trust Sanger Institute (Hinxton, UK) as a Group Leader, and in 2009 was appointed as a Professor of Systems Biology at University College London.