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UCL Division of Biosciences

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Dr Emmanuel Boucrot

Dr Emmanuel Boucrot

Associate Professor

Structural & Molecular Biology

Div of Biosciences

Joined UCL
1st Sep 2011

Research summary

Understanding molecular mechanisms and establishing functions of intracellular membrane trafficking in health and disease. 

Current Project: Mechanisms of Fast Endophilin-Mediated Endocytosis (FEME)

Endocytosis is the process by which cells acquire substances from the extracellular space and  internalise transmembrane cell surface proteins, of which receptors are a major class. The process occurs through invaginations of the plasma membrane forming endocytic vesicles that, once pinched off the surface, are transported to endosomes and, from there, sorted to the appropriated cellular destinations depending on the fate of the receptor. We recently identified a new pathway of endocytosis, the Fast Endophilin-Mediated Endocytosis (FEME) pathway (Boucrot et al. 2015 Nature; Renard et al. 2015 Nature; Chan Wah Hak et al. 2018 Nat Cell Biol). Our goal is to establish the functions and molecular mechanisms of this novel route of entry into cells.

This project is funded by a 2014 Lister Institute Research Prize

Current group members:

Ms Alessandra Casamento (PhD student funded by BBSRC)

Mr Shaan Subramanian (PhD student funded by MRC)

Alumni: Ms Claudia Hinze (PhD student to graduate 2018, now PDRA at UCL), Dr Antonio PA Ferreira (PhD student 2011-2016, now PDRA at Harvard University, US), Dr Kieran McGourty (PDRA, 2012-2016, now Lecturer at U. of Limerick, IRL), Dr Ana Mendes Pereira (PDRA, 2012-2016, now Senior Scientific Officer at King's College London, UK), 

Teaching summary

Career break until 2021 (family reasons)

Education

Other Postgraduate qualification (including professional), ATQ03 - Recognised by the HEA as a Fellow |
PGCE, PGCE. |
Universite de la Mediterranee (Aix Marseille II)
Doctorate, Doctor of Philosophy | 2005
Universite de la Mediterranee (Aix Marseille II)
Other higher degree, Master of Research | 2001
Universite de Geneve
Other higher degree, Master of Science | 2000
Universite de Geneve
First Degree, Bachelor of Science | 1998

Biography

2019 - 2021    Career break (family reasons)

2018               Wellcome Trust Birkbeck Institutional Strategic Support Fund Career Development Award

2017               Fellow of the Royal Society of Biology (FRSB) 

2016               Associate Professor in Molecular Cell Biology 

2015               Fellow of the Higher Education Academy (FHEA)

2014               Lister Institute Research Prize 

2011 - 2016    BBSRC David Phillips Research Fellow, University College London, London (UK)

2008 - 2011    MRC Career Development Fellow, MRC Laboratory of Molecular Biology, Cambridge (UK)
2006 - 2008    HFSP Postdoctoral Fellow, Harvard Medical School, Boston (US) 

2005 - 2006    EMBO Postdoctoral Fellow, Harvard Medical School, Boston (US) 
2001 - 2005    PhD in Immunology, University of Aix-Marseille II, Marseille (France) 


Publications: 31 research papers, 9 review articles. h-index 26, over 8,000 citations


Selected research papers: 

- Chan Wah Hak L et al. and Boucrot E(2018) 'FBP17 and CIP4 recruit SHIP2 and Lamellipodin to prime the plasma membrane for Fast-Endophilin-Mediated Endocytosis' Nat Cell Biol  20 (9) pp.1023-31 

- Boucrot E$ et al. (2015) 'Endophilin marks and controls a clathrin-independent endocytic pathway' Nature  517 (7535) pp.460-5

- Boucrot E* et al.  (2012) 'Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains' Cell 149 (1) pp.124-36

- Henne WM*, Boucrot E*,$ et al. (2010) 'FCHo proteins are nucleators of clathrin-mediated endocytosis'  Science  328 (5983) pp.1281-4    

- Boucrot E et al. (2005) 'The intracellular fate of Salmonella depends on the recruitment of kinesin'  Science 308 (5725) pp.1174-8

  

* joint first authors    $ corresponding author

Full list of publications

Publications