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UCL Division of Biosciences

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Guardian newspaper features interview with UGI's Dave Curtis

8 October 2018

The article highlights concerns that polygenic risk scores for diseases are largely developed from studies of white, European subjects and hence cannot be applied to subjects from ethnic minorities.

This is an especially important issue now that some people are advocating that these risk scores could be used in clinical situations, because it means that people from ethnic minorities will not gain benefits from this field of medical research. The problem is highlighted by a paper published in the Psychiatric Genetics journal, which showed that the polygenic risk score for schizophrenia was ten times as high in African subjects as in European subjects, rendering it useless for non-European populations.

Read full article: Genetics research 'biased towards studying white Europeans'
Read full paper: Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia
Author: David Curtis