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A novel mode of extrusion of potential cancer cells from a healthy tissue

30 November 2018

Cell and Developmental Biology

A novel mode of extrusion of potential cancer cells from a healthy tissue

A healthy tissue has ability to detect and eliminate potential cancer cells as part of the defensive mechanism. Based on live imaging, the Tada lab uncovered a new mode of extrusion of potential cancer cells using the zebrafish embryonic epithelium as a model for the early stage of cancer development. Potential cancer cells can pop out of the tissue at the timing of cell division: two sides of the same coin, division and extrusion. We hope that our finding is a first step to effectively eliminate potential cancer cells out of the body at the earliest stage.

Read full paper: Src-transformed cells hijack mitosis to extrude from the epithelium
Authors: Katarzyna Anton, Mihoko Kajita, Rika Narumi, Yasuyuki Fujita, Masazumi Tada