A novel mode of extrusion of potential cancer cells from a healthy tissue
30 November 2018
Cell and Developmental Biology
A healthy tissue has ability to detect and eliminate potential cancer cells as part of the defensive mechanism. Based on live imaging, the Tada lab uncovered a new mode of extrusion of potential cancer cells using the zebrafish embryonic epithelium as a model for the early stage of cancer development. Potential cancer cells can pop out of the tissue at the timing of cell division: two sides of the same coin, division and extrusion. We hope that our finding is a first step to effectively eliminate potential cancer cells out of the body at the earliest stage.
Read full paper: Src-transformed cells hijack mitosis to extrude from the epithelium
Authors: Katarzyna Anton, Mihoko Kajita, Rika Narumi, Yasuyuki Fujita, Masazumi Tada