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New paper from the Patel lab published in Cell Reports identifies Ca2+ as a key regulator of physical junctions between organelles

16 February 2017

Endosomes form junctions with the endoplasmic reticulum (ER) but how such proximity is regulated is unclear.

Patel Cell Reports Image The paper by joint first authors Bethan Kilpatrick and Emily Eden shows that release of Ca2+ by an endosomal ion channel facilitates inter-organellar coupling to temper signals mediated by an internalised growth factor. Endosome-ER contact sites thus emerge as Ca2+-dependent signalling hubs.

This BBSRC-funded study was a result of a collaboration between the labs of Sandip Patel and Clare Futter (Institute of Ophthalmology).