Endosomes form junctions with the endoplasmic reticulum (ER)
but how such proximity is regulated is unclear.
by joint first authors Bethan Kilpatrick
and Emily Eden
shows that release of Ca2+
by an endosomal ion channel facilitates inter-organellar coupling to temper
signals mediated by an internalised growth factor. Endosome-ER contact sites
thus emerge as Ca2+-dependent signalling hubs.
This BBSRC-funded study was a result of
a collaboration between the labs of Sandip Patel and Clare Futter (Institute of Ophthalmology).