UCL Division of Biosciences


Circuits and Systems Neuroscience

Research in the Circuits and Systems laboratories in the department focuses on understanding the fundamental mechanisms of circuit and system function and how it contributes to emerging behaviours in health and disease. Laboratories use a combination of cutting-edge optical, genetic, pharmacological and electrophysiological techniques to measure and manipulate brain activity from a variety of cell-types to dissect and interrogate the circuit function.


Common methodological approaches are used in the department to investigate a number of different themes, including sensory systems, hippocampal function, metabolic and cardiovascular physiology, neuroplasticity and learning, and pain. These systems are investigated during development, in adulthood and in ageing, and in different model systems, including rodents and zebrafish, as well as in humans.


These laboratories share common goals of understanding the structure and function of circuits in the brain, how they change and how they underpin behaviour.

Major Themes Include:

  • Cardiovascular and Metabolic Neurophysiology
  • Synaptic and Circuit Correlates of Behaviour
  • Sensory neuroscience
  • Developmental Biology
  • Neuroplasticity and Learning
  • Physiology of Pain

People involved in this research theme:

Recent Papers

Learn More

YouTube Widget Placeholderhttps://www.youtube.com/watch?v=Qi0xmQR0Qzw&t=6s


David Attwell: UK DRI – The role of capillary pericytes in health, stroke and Alzheimer's disease

YouTube Widget Placeholderhttps://www.youtube.com/watch?v=uGt8d6QIUJA&t=5s


David Attwell: Physiology 2021: Annual Review Prize Lecture 

YouTube Widget Placeholderhttps://www.youtube.com/watch?v=qb73zTbarWQ&t=8s


Francesca Cacucci: The post-natal development of the hippocampal networks for memory and space

YouTube Widget Placeholderhttps://www.youtube.com/watch?v=2hwU_VNtQmA


Lorenzo Fabrizi: Interview with the Medical Research Foundation

YouTube Widget Placeholderhttps://www.youtube.com/watch?v=_AR0q9w33sw&t=12s


Maria Fitzgerald: Ethical issues of neuroscientific studies on fetuses and newly born babies

YouTube Widget Placeholderhttps://www.youtube.com/watch?v=X40GFffgF48


Marie Holt (Trapp Lab): Mind affects matter – brainstem circuits linking stress, physiology, and behaviour

Tara Keck: Neuroplasticity in Isolation and Loneliness

Stephanie Koch: Touch, pain and itch