MSc Pharmacogenetics and Stratified Medicine
The MSc in Pharmacogenetics and Stratified Medicine will provide scientists and clinicians with an in-depth knowledge of: the pharmacology of drugs; the consequences of drug treatment for individuals with respect to their genotype; the analysis and statistical methods used to study population groups and how this knowledge can be applied to improve human health, drug efficacy and alleviate human disease through the development and application of diagnostic tests or therapeutic agents.
UCL is a leading centre of internationally recognised research in the field of pharmacology, biochemistry and human genetics and these strengths, both academic and clinical, are being harnessed to bring together this cross-faculty initiative in a rapidly growing area of science. UCL is in a unique position to offer students both the basic science and application of pharmacogenetics to improve human health, including multidisciplinary outreach across the college.
The programme is designed for those with undergraduate qualifications in the life sciences, individuals from the pharmaceutical and biotechnology industries, scientists and clinicians. The knowledge and transferable skills developed in the course will be suitable for those in an industrial or healthcare setting, as well as those individuals contemplating further PhD studies.
Students emerge well-versed in the different tools and scientific disciplines which will allow them to make full use of the wide ranging genetic discoveries that have happened over the past decade and will increasingly inform our understanding of human biology and disease. This positions them well for studentships in laboratories using genetic techniques to examine diseases such as heart disease, cancer and neurological disorders. Another large group will seek research jobs in the pharmaceutical industry, where an advanced training in laboratory genetic techniques as well as bioinformatic and statistical experience will be of value.
The MSc in Pharmacogenetics and Stratified Medicine
programme is offered full-time over 12 months. It is divided into three
parts: compulsory core modules, optional modules and a dissertation
project (120 credits taught: 60 credits research project).
A Postgraduate Diploma (total 120 credits) comprising of four core modules (60 credits) and two optional modules (30 credits) is available.
A Postgraduate Certificate (total 60 credits) comprising of four core modules is available.
- Molecular Pharmacology
- Clinical Applications of Pharmacogenetic Tests
- Drug Design and Development
- Human Genetics in Context
- Core Skills
- Basic Statistics for Medical Sciences
- On-line lectures on Principles of Human Genetics
- Pharmacogenomics, adverse drug reactions and biomarkers
- Anti-cancer personalised medicines
- Genetics of Cardiovascular Disease
- Genetics of Neurological Disease
- Pharmacology of Inflammation
- Computational and Systems Biology: in Silico Analysis of Genes and Proteins and their Biological Roles
This is the practical part of the programme and will consist of an original piece of research. Assessment of these courses will be by an oral presentation and a written dissertation (60 credits.
Examples of Projects
- Hereditary haemochromatosis mutation and polymorphism: investigation of of HFE and HAMP as a risk factors for CVD
- Fine scale genotyping and use of tSNPs for AFAMIN in relationship to Metabolic Syndrome and T2D and CHD risk
- Meta-analysis of interaction between APOE genotype and smoking on CHD risk
- Obesity, Infl;ammation and Oral infections: are microRNAs the missing link?
- Identification of novel urinary biomarkers of hepatic injury in the Han Wistar rat
- The role of Keap1 mutations found in lung cancer in perturbing protein-protein interactions with its binding partners
- A locus-specific databases for the drug-metabolizing enzymes FMO1 and FMO3
- Defining the role of Coenzyme A in signalling pathways
- Diversification of purinergic receptor signalling via the formation of nucleoside: nucleotide receptor heteromers
- Functional properties of GluN2B subunit and GluN2D subunit –containing NMDA receptors in dopaminergic neurones of the substantia nigra
- Identification and functional characterization of polymorphisms that are important in pharmacogenetics
- Iron regulation of lipid metabolism in a model of atherosclerosis
- Personalised Medicine in Children: effect of age and genetics on CYP2C9-mediated clearance of diclofenac
- Expression of mitochondrial biogenesis genes after exposure to ketones and fatty acids
- Role of NADPH oxidase subunits in NOD2 signalling
- Studies on the molecular basis of Gemcitabine resistance in a pancreatic cancer cell line Mia PaCa-2
- Predisposing risk factors of EPS, weakened metabolic activity and paradoxical effects observed during Olanzapine treatment
An MSc will be awarded on satisfactory completion of the compulsory
modules, optional modules and a dissertation based on an original piece
of work of research.
a minimum of an upper-second class UK Bachelor's degree in biomedical
sciences or medical discipline from from a UK university or an overseas qualification of an equivalent standard.
Applicants with an appropriate professional qualification and relevant
work experience may also apply. Applicants should be confident using
computers and show some evidence of numeracy (minimum GCSE Mathematics
or statistics or a module with a good mark in their degree).
All prospective students should see our Graduate Prospectus
The Institute welcomes applications from international students. Students whose first language is not English, are required to provide evidence of their ability to understand and speak and write English to a standard that will ensure that language problems do not impede their academic progress. UCL accepts a number of qualifications including the British Council International English Language Testing System (IELTS).
Language Centre offers both a one-year full-time Certificate in English
for Special Purposes and a range of pre-sessional English Language
Courses for those who do not meet UCL's minimum standard.
- International English Language Testing System (IELTS)
- Language Centre
- Certificate in English for Special Purposes
The International Office is a centre of expertise and advice for overseas students, who are welcome to seek help or guidance in many areas such as immigration, housing, finance, English Language, tuition and fees.
Application should be submitted directly to UCL Admissions
The 2015-16 session closing date for UK/EU students is 31 July 2015 and for overseas students is 30 June 2015. Please apply early to avoid disappointment.
There is a maximum of 20 students accepted onto the program per year.
Student Tuition fee details can be found on our Student Fee Schedule Page.
Please go the UCL Scholarship page:
Applications for funding from any of the links below need to be made independently of your application for the MSc
GREAT - UCL India Scholarship
This scholarship is awarded on the basis of academic excellence, achievement and potential.
Page last modified on 21 oct 14 15:50