Please note that this is a provisional list. The selection of modules will not be made until the start of the course. Advice will be given by the Subject Tutors on selection taking into account the interest of the student, relevance to the Research Project and the previous academic experience of the student. Some modules may be appropriate for more than one subject stream.

Structural Biology and Molecular Biophysics - Taught modules (Select one from the following)

Mechanisms of Molecular Machines I
Molecular Mechanisms of Gene Expression and Regulation
Cellular and Molecular Aspects of Cardiovascular Disease

Subject Stream Tutor Prof. Chris Kay tel +44 20 7679 7312 (x37312 internal)

Research Interests

Please note that you only choose your Research Project at the start of the course following advice from the subject tutor. The information given here is just to give you a "flavour" of the options and for you to think about the topic that particularly interests you.


The MRes in Structural Biology and Molecular Biophysics will focus on biophysical methods for elucidation of protein structure and function. Topics of the research projects will include important areas such X-ray crystallography, cryo-electron microscopy, magnetic resonance (NMR & EPR), FRET, FT-IR, circular dichroism, surface plasmon resonance, microcalorimetry and analytical ultracentrifugation. The projects will be supervised by members of the biophysics group at the Institute of Structural & Molecular Biology which brings together scientists at UCL and Birkbeck College.

Example Project Titles include:

Crystallography of a calcineurin targeting complex involved in learning and memory
Dr Matthew Gold

Structural studies of pilus biogenesis in E. Coli by nitroxide spin-labelling and EPR spectroscopy
Prof Chris Kay, Prof Gabriel Waksman

Structural studies of an Hsp90 cochaperone is the assembly of the yeast kinetochore
Dr Cara Vaughan

The polymerization mechanism of Alpha-1 Antitrypsin by nitroxide spin-labelling and EPR spectroscopy
Prof Chris Kay

Flavin interaction with M.tuberculosis nitroreductases
Prof Nick Keep

Multidisciplinary studies of the interactions of recombinant human complement factor H with its major physiological ligands by AUC, AUC-FDS, SAXS, SANS, SPR, DPI and/or modeling
Prof Steve Perkins

Crystallisation of wildtype and mutant forms of yeast cytochrome c oxidase for structure determination.
Prof Peter Rich

Electron tomography of prion-infected yeast cells
Helen Saibil

Bacteriophage encoded inactivation of cellular DNA repair
Dr Renos Savva

Deciphering and editing transcription factor - response element interactions
Dr Renos Savva, Prof David Jones

Cloning, Expression, Purification and Structural Studies of Voltage Gated Ion Channels
Prof Bonnie Wallace, Dr Claire Bagneris

Structural Studies of Bacterial type IC secretion Systems
Prof Gabriel Waksman

Page last modified on 19 nov 14 09:44