4-year PhD in Neuroscience We have already selected students for 2019. Future application deadlines will be posted here. Currently we have no funding for further student entries to the programme.
Why study Neuroscience at University College London?
Outstanding research opportunities
University College London (UCL) offers unrivalled opportunities for PhD research in all aspects of neuroscience. Specimen PhD projects are given below: the subjects studied range from the molecular biology of neuronal proteins, through cellular neuroscience, to the behaviour of sensory and motor systems and brain imaging. Neuroscience research is carried out in all of the College's biomedical departments, by researchers who are among the leaders of their fields, using the most modern techniques to address important problems of basic and clinical neuroscience. Research labs are well-funded, so that PhD students have the best chance of getting off to a productive start in their research.
UCL produces the highest quality neuroscience research of any university in the country. A Rand Report has shown that it produces the highest quality neuroscience research of any UK university. For neuroscience it generates the highest percentage (18%) of England's contribution to the world's most highly cited publications, which is twice as much as Cambridge or Oxford. For neuroimaging it also produces the highest percentage (21%) of England's contribution to the world's highly cited papers, which is 70% larger than Oxford and three times more than Cambridge. Confirming this analysis, Thomson ISI (Web of Science - Essential Science Indicators) rate UCL as the 2nd university in the world and 1st university in Europe for number of citations to research papers in Neuroscience & Behaviour over 2008-2018. Accordingly it is an outstanding place to train the next generation of neuroscience researchers.
Cultural and social opportunities provided by London
UCL is located in Bloomsbury, close to the entertainment areas of the West End and South Bank which offer an enormous range of music, art, theatre and film, and a vast number of restaurants and bars. London is extremely socially diverse: most PhD students rapidly establish a thriving social life.
Why choose to study Neuroscience in the 4-year Programme?
Because the 4-year Programme provides a better training, equipping students with the experimental and theoretical techniques needed to do outstanding research in their future career (see tab below on Student Outcomes).
Deficiencies of 3-year PhDs
Conventional 3-year PhDs involve a student working with a supervisor who they often have little knowledge of before they start, on a project which they have little prior understanding of. The resulting training can be rather narrow (limited to learning the techniques offered by that one lab), and students sometimes select supervisors or projects which are not best suited to them.
Structure of the 4-year programme
Value of the first year
The four year programme provides a broader and deeper research training in neuroscience, and allows students to make a more informed choice of supervisor and project. This is achieved by having an initial training year in which the students attend some specialized courses, and do three brief (3 month) research projects in different labs. Out of the three broad subject areas of Molecular Neuroscience, Cellular Neuroscience and Systems Neuroscience & Imaging, students will choose laboratories from at least two areas, in order to maintain a broad expertise across neuroscience in the first year. By working in different labs, the students will have the opportunity to acquire a broader range of experimental and theoretical techniques, and to try out supervisors with whom they may wish to do research for the PhD. For the structure of the 1st year please refer to the tabbed panel 'Year 1 Structure' section below.
The 3 PhD years
After their first year, students will work in one lab doing research for the PhD (this might be one of the labs they worked in during the first year, or a different lab). During the PhD students will be encouraged to attend advanced training courses in the USA and Europe. For supervisors available for PhDs please refer to the tabbed panel 'Supervisors' section below.
Throughout the 4 years, the student's progress will be monitored and assessed by a committee responsible for the training provided. Students will be integrated into the community of neuroscience researchers at UCL by participation in journal clubs and social events. Career advice will be given in the last year to prepare the student for their post doctoral career.
The 4-year PhD Committee
The committee currently comprises David Attwell, Sarah-Jayne Blakemore, Patricia Salinas and Alasdair Gibb, and students can approach any of the committee members for advice and guidance when needed.
Student experiences and outcomes
Want to read about students' experiences on the 4 year programme? - they are described in Trends in Neurosciences (July 2000) Vol 23, pages 280-283. An assessment of how well the students do scientifically on the programme is given in the tabbed panel 'Student Outcomes' section below.
If you have any questions...
Molecular Neuroscience Cellular Neuroscience Systems/Cognitive Neuroscience
Molecular Basis of Huntington's disease
Neuron-glial interactions and brain energy supply
Learning, Memory and Infreence
Voltage-dependent calcium channels
Genes and circuits for innate and learned behaviours in C. elegans
Wearable brain scanners
Glial roles during brain development
Glycinergic inhibition in the ventral spinal cord
Memory, space, and hippocampal networks
Motor neuron degeneration and genes
Zebrafish circuits and behaivour
Genes and circuits for innate and learned behaviours in C. elegans
Storing and updating models of the world for controlling behaviour
Molecular basis of neuronal second messaging
Computation of instinctive decisions
Neural Coding of Perception and Memory
Genomic and cellular investigation of neurodegeneration
Neural circuits for nociception and pain
Decision implementation and action preparation
Molecular basis of frontotemporal dementia and amyotrophic lateral sclerosis
Cell Biology of Neurodegeneration
Auditory and auditory-visual perception
Cellular functions of the prion protein
Neuronal activity, mitochondrial function and cell death
Neural circuits for movement
Ionotropic GABA and glutamate receptor signalling
Neural networks and hippocampus
Cell development and regeneration
Hippocampal neural circuits
Cell biology of the synapse
Ion channel receptors and synaptic transmission
Sensory representation by neuronal populations
Human cerebral cortex development and disease
The Graham Watts Laboratories for Research into Motor Neuron Disease
Emotion and decision making
Alison C Lloyd
Peripheral nerve regeneration and cancer
A developing social brain circuit
Neuronal nicotinic acetylcholine receptors
Microglia-synapse biology in brain function and dementia
The Developmental Biology of Spinal Cord and Cortical Pain Processing
State-dependent neural processing
Visual perception & psychophysics
Transcriptional and epigenetic mechanisms in developing neurons
Control of human action
Neuroglial stem/progenitor cells
CNS synaptic transmission, epilepsy, and inherited mutations of ion channels in neurological disease. State-dependent neural processing
Computation in cortical circuits
Synaptic and circuit basis of emotional behaviour
The neural representation of space and context
Cell signalling in synaptic plasticity and synapse degeneration
Cellular and molecular mechanisms of glial morphogenesis
Cortical synaptic plasticity
Ion channels and disease
Cell cycle and neural development
Neuronal mechanisms of learning and decision making
Ion channels as single molecules
Neuronal calcium signalling by NAADP
Action observation: perceptual learning and inference
Trevor G Smart
Molecular pharmacology of GABA and glycine receptor-ion channels
Rachael A Pearson
Stem Cell Therapy and Retinal Degeneration
Action observation: perceptual learning and inference
Ion channels regulating neuronal excitability and firing properties
Cortical and subcortical mechanisms of movement generation and inhibition
Molecular pharmacology and physiology of potassium channels
Principles of synaptic signal formation in the brain
Predictive sensorimotor control in central fatigue
Structure and function of neuronal protein-RNA complexes
Axonal transport in health and disease
Network dynamics and neural coding
Circadian clocks in zebrafish
Voltage-gated ion channels
Attention and Cognitive control
Zebrafish CNS development
Synaptic transmission and neural computation
Population coding in sensory systems
Molecular genetics of sensory neurons
Pathophysiology of neuroinflammation
Brain mechanisms for perception of complex sounds
Cellular mechanisms of neurodegeneration
The neural basis of spatial and episodic memory in humans
Mechanisms of neurotransmitter release in health and in neurological disease
Human brain plasticity
Mechanisms and treatment of epilepsy
Benedetto De Martino
Value Computation, Uncertainty and Choice
Cognitive neuroscience of attention & awareness
Neural basis of motivation and emotion
Theoretical Neuroscience and Machine Learning
Neural circuits that transform visual information to spatial memories
Information Processing and Belief Formation
Plasticity and recovery in health and disease
Clinical neuroscience of complex sound
- Year 1 Structure
Structure of the First Year of the 4 Year PhD
The first year has 3 main components, compulsory courses, optional courses and (occupying most of the time) three 3 month laboratory placements spent doing research and learning techniques.
These consist of:
An Induction course introducing you to the College
A course on Current Techniques in Neuroscience
A Topics in Neuroscience course, structured like a journal club in which you present research papers
A Statistics course
A course on Library and Database Usage
An Electronics course
A course on the Ethics of Animal Experimentation
Two Neuroscience courses chosen from the Optional list below
Attending Journal Clubs associated with the lab placements (see below)
A Science Communication course (may also be taken in the 2nd year)
These consist of:
Computing Courses on E-mail, Word Processing, Internet, Spreadsheets, Powerpoint, Visual Basic, and more advanced programming
A Mechanical Workshop course
A Further Statistics course
A Radiation Safety course
Orientation for Foreigners
English for Foreigners
The following Neuroscience Courses:
Neural Basis of Learning + Motivation
Neurobiology of Neurodegenerative Disease
Cellular + Developmental Neurobiology
Control of Movement
Peripheral Nervous System
Animal Cell Biology
Develpmantal Biology: Cell + Molecular Aspects
Molecular + Cellular Pharmacology
Neurobiology of Behaviour
Neurobiology of Vision
Journal clubs in the rotation labs
The Laboratory Placements
Three of these are done, chosen from labs working in the broad areas of Molecular Neuroscience, Cellular Neuroscience, and Systems and Imaging Neuroscience. Students must choose 3 placements covering at least 2 of these broad areas (in order to avoid over-specialization in the first year). For example, students might do a placement in one lab which they think they might want to do their PhD research in, one in a similar lab for comparison, and one in a lab studying something quite different to gain experience in another area. Students doing these placements often publish papers on their work, or present it at scientific meetings.
For information on supervisors and projects refer to the supervisors tab
Student progress during the first year is assessed by:
(i) exams on the Topics in Neuroscience course, the Ethics of Animal Experimentation course and on the Statistics course
(ii) a write-up and 10 minute oral presentation on each lab placement
(iii) their placement supervisor's assessment of their work
(iv) their contribution to journal clubs they attend
(v) the writing of a research plan outlining their proposed PhD project for the subsequent 3 years.
- Student Outcomes
We currently receive about 400 applications per year from all over the world. From these, we select 30 applicants for interviews which assess knowledge, creativity and data interpretation. From these 30 candidates, we choose 5 for the places available on the PhD Programme. Our selection ratio of women:men closely reflects the ratio of women to men applying (over 22 years, out of 142 students selected 59.9% were women and 40.1% men). BME students, defined conventionally to include Asians and mixed race students, comprise 8.5% of accepted students.
How well do the students in the programme do scientifically?
We analysed this after 10 years of the programme being in operation.
As of April 2007, the students going through the programme since 1996 have published a total of 251 journal papers since entering the programme, with 28 (11%) high profile papers in Nature family journals, Science, Cell or Neuron.
Five years after starting the programme, the 15 students in the first three years' entry had published 80% more papers/student than the average of all 123 three year PhD students recruited to the same departments at the same time. One might hypothesise, however, that this superiority of the 4 year students could reflect the 3 year PhD students being less selected or working with weaker supervisors. To assess whether the 4 year programme confers particular benefits, we therefore carried out tougher comparisons, that were not confounded by the inclusion of weaker supervisors who we do not allow onto the programme, or by the selection bias inherent in our admission process. We did this as follows.
First we removed supervisor bias, by comparing the output of students in our programme with the output of matched 3 year PhD students who did a PhD in the same lab at approximately the same time (all except 5 of the 66 1996-2004 students could be matched). The results are plotted in Figure 1 as absolute number of papers, and in Figure 2 as the relative productivity of 4 and 3 year students (1 is added to the number of papers before taking the ratio to avoid divisions by zero). From 7 years after starting, the productivity of 4 year students increases significantly (Fig. 2) above that of 3 year PhD students with the same supervisors. Students in the first 3 entry cohorts have now received 2621 citations of their papers, compared with 1421 citations of the papers of matched 3 year students in the same labs (84% more).
Secondly, to eliminate effects of the higher selection to which our students were subjected, we compared the output of our 4 year students, with the output of students who we made an offer to but who chose to take up a place on a 3 or 4 year PhD elsewhere. This ensures that the comparator students were viewed by our committee as being at least as good as the accepted students. The results (Figure 3) show a significantly higher output, from 7 years after starting the course, by our 4 year students than by students who rejected our offer.
We conclude that going through the first year of the 4 year PhD adds significant long-lasting value to the students' scientific training.
Career Path after the PhD
Most of the students follow a career in research. As of 2007, of the 37 students who have obtained their PhD, 29 (78%) went on to post-doc positions, 6 went to science-related jobs (drug companies, scientific administration, patent agency or management consultancy) and 2 left science, so overall 95% (35/37) took up positions using their science. The earlier cohorts are now starting to obtain permanent academic positions or Career Fellowships: one is a lecturer at the Royal Vet College, 3 are Royal Society Dorothy Hodgkin Fellows at UCL, one has a 5 year Faculty position at EBRI (Rome), one is an MRC CDF in Leicester, one is a Wellcome RCDF at UCL, two have permanent positions in Edinburgh.
The images at the top of this page
The pictures at the top of this page show different levels of function of the nervous system.
The left hand picture shows cellular interactions between neurons: the axon of an inhibitory interneuron (green) makes synapses onto a cerebellar Purkinje cell (red) in the brain's motor system. Image by Beverley Clark and Michael Häusser.
The middle picture shows information superhighways in the brain: the gold colour shows antibody to myelin, which speeds the conduction of information along neuronal axons in the brain's white matter. Image by Ragnhildur Káradóttir and David Attwell.
The right hand picture shows function at the whole brain level: the red and yellow colour shows areas where neurons are detected to be active using fMRI (functional magnetic resonance imaging) during a particular task, superimposed on a structural image of the brain. Image courtesy of Sarah-Jayne Blakemore and the Wellcome Trust Centre for Neuroimaging, UCL.