CDB Seminar - Prof Ville Hietakangas, University of Helsinki

Please join us for a CDB Seminar by Prof Ville Hietakangas of the University of Helsinki.

'Nutrient regulation of cell fate and turnover – an organ-wide approach'

Zoom at: https://ucl.zoom.us/j/91442854347 *

*please note: this talk will not be recorded

Talk abstract: Nutrient intake impacts the homeostasis of adult organs: in addition to metabolic changes, nutrients can affect organ size, cellular composition and turnover. Spatial heterogeneity of organ physiology is currently emerging, but how it is reflected to the control of organ homeostasis remains poorly understood. I will discuss our work on the Drosophila midgut, using an organ-wide approach to understand the molecular mechanisms mediating nutrient control of cell fate and turnover in a region-specific manner.

Suggested references:

• Mattila J, Viitanen A, Fabris G, Korzelius J, Hietakangas V. Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation. Science Advances, 2024, 10:eadi2671.
• Viitanen A, Gullmets J, Morikka J, Katajisto P, Mattila J, Hietakangas V. LAM – an image analysis method for regionally defined organ-wide cellular phenotyping of the Drosophila midgut. Cell Reports Methods, 2021, 1: 100059

Host: Marc Amoyel