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CDB Seminar - Professor Takashi Hiiragi, Hubrecht Institute
27 April 2023, 12:00 pm–1:00 pm
Title: Multicellular coordination in space and time
This event is free.
Event Information
Open to
- All
Availability
- Yes
Cost
- Free
Organiser
-
Michael Wright – Cell and Developmental Biology
Talk abstract: A defining feature of living systems is the capacity to break symmetry and generate well-defined forms and patterns through self-organisation. Our group aims to understand the design principle of multi-cellular living systems using early mammalian embryos as a model system. We developed an experimental framework that integrates biology, physics and mathematics, to understand how molecular, cellular and physical signals are dynamically coupled across the scales for self-organisation. I will discuss our ongoing work investigating how developmental mechanisms are coordinated in space in time.
Suggested references:
Korotkevich, E., Niwayama, R., Courtois, A., Friese, S., Berger, N., Buchholz, F. and Hiiragi, T. The apical domain is required and sufficient for the first lineage segregation in the mouse embryo. Developmental Cell (2017) 40(3), 235–247.e7.
Maître, J.-L., Turlier, H., Illukkumbura, R., Eismann, B., Niwayama, R., Nedelec, F. and Hiiragi, T. Asymmetric division of contractile domains couples cell positioning and fate specification. Nature (2016) 536(7616), 344–348.
Host: Masa Tada
Zoom: https://ucl.zoom.us/j/96539312758
PLEASE NOTE - THIS TALK WILL NOT BE RECORDED
About the Speaker
Professor Takashi Hiiragi
Group Leader at Hubrecht Institute
Takashi Hiiragi is group leader at the Hubrecht Institute. The Hiiragi group aims to understand what defines multi-cellular living systems. In particular, the group studies the design principle of tissue self-organization, using early mammalian embryos as a model system. To this end, they developed an experimental framework that integrates biology, physics and mathematics. Their recent studies led to a model in which feedback between cell fate, polarity, and cell and tissue mechanics underlies multi-cellular self-organization. The group adopts a wide variety of experimental strategies including embryology, genetics, advanced microscopy, biophysics, engineering and theoretical modelling, in order to address fundamental questions in cell and developmental biology.
More about Professor Takashi Hiiragi