CDB Seminar - Nuria Flames Bonilla

Talk abstract: The brain's ability to fulfil highly sophisticated tasks requires a profuse number of different neuron types that display an exquisite degree of specialisation. In my lab we study how the terminal identity of each neuron type is established during development and maintained throughout the life of the animal. We also are interested in understanding the molecular mechanisms that drive the emergence of new neuronal types, novel functions and innovative behaviours in evolution. In our studies we take advantage of the small genome size of Caenorhabditis species, their amenability to genetic manipulations and the invariable cellular lineage, that consistently generates 302 neurons classified into 118 neuron types, to gain insights into these processes at the single-cell level and across species.

Suggested references:

Transcriptional regulation of neuronal identity. Sousa E, Flames N.Eur J Neurosci. 2022 Feb;55(3):645-660. doi: 10.1111/ejn.15551. Epub 2022 Jan 18.PMID: 34862697

Joint actions of diverse transcription factor families establish neuron-type identities and promote enhancer selectivity. Jimeno-Martín A, Sousa E, Brocal-Ruiz R, Daroqui N, Maicas M, Flames N.Genome Res. 2022 Mar;32(3):459-473. doi: 10.1101/gr.275623.121. Epub 2022 Jan 24.PMID: 35074859

A transcription factor collective defines the HSN serotonergic neuron regulatory landscape. Lloret-Fernández C, Maicas M, Mora-Martínez C, Artacho A, Jimeno-Martín Á, Chirivella L, Weinberg P, Flames N.Elife. 2018 Mar 22;7:e32785. doi: 10.7554/eLife.32785.PMID: 29553368

Host: Richard Poole

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https://ucl.zoom.us/j/91750044687 Meeting ID: 917 5004 4687