Biosciences Events

CDB Special Seminar - Professor Barbara Conradt - 26 January 2018

Title: C. elegans as a model for studies on apoptosis regulation and mitochondrial stress response pathways
Speaker: Professor Barbara Conradt - Cell and Development Biology, Ludwig-Maximilians-University München (lab page)
Venue: JZ Young LT, Anatomy Building (map)
Host: Dr Richard Poole (email)
Abstract: BH3-only proteins, which belong to the family of Bcl-2-like proteins, have proven to be key activators of apoptosis in animals as diverse as nematodes and mammals. By focusing our analyses on specific cell deaths, we have obtained a comprehensive understanding of how the activity of the C. elegans BH3-only protein EGL-1 is controlled during development. In addition, we have been able to uncover novel aspects of apoptosis regulation. Finally, during our studies on apoptosis in C. elegans, we found that mitochondria fragment in cells that die, a phenomenon that is conserved in mammals. This fragmentation is mediated by dynamin-related GTPases, which control mitochondrial dynamics. Following this line of investigation, we have begun to study stress response pathways that are induced in response to changes in mitochondrial dynamics.

Starts: Jan 26, 2018 1:00:00 PM