Title: SLC16A and P5B transporters conspire to offset the effects of TRPM channel deficiency in C. elegans.
Speaker: Dr Eric Lambie - Cell and Developmental Biology, Ludwig-Maximilians-University München, Germany (research profile)
Venue: G06 Sir Ambrose Fleming LT, Roberts Building (map)
Host: Professor Leslie Dale (email)
Abstract: TRPM channels are mediators of cellular cation influx that originated in a common ancestor of modern metazoans. TRPM channels are permeable to a range of divalent and monovalent cations, and we have found that they are particularly important for the maintenance of organismal magnesium homeostasis. By screening for loci that modify the effects of TRPM channel deficiency in C. elegans, we identified mutant alleles in representatives of two other types of conserved proteins, the SLC16A and P5B transporters. SLC16A transporters are major facilitator superfamily proteins that include the mammalian monocarboxylate transporters. P5B transporters are P-type ATPases with unknown substrate specificity that are critical for the survival of human dopaminergic neurons. We are working to understand the mechanistic basis for the genetic interactions between these different types of proteins.
Starts: Apr 23, 2018 12:00:00 PM
Title: How good are we at predicting the effects of environmental change on animal population trends?
Speaker: Fiona Spooner, PhD student, Dr Richard Pearson lab (research profile)
Venue: G04 Anatomy Gavin de Beer LT (map)
Abstract: Since 1970 it is estimated that there has been a 58% decline in vertebrate abundance. These declines have occurred alongside rapid, human-driven environmental change, including climate change. Being able to accurately predict the impacts of these changes on biodiversity is crucial to effective conservation, yet it is rare for the accuracy of predictions to be assessed against observed data. Here I will present assessments of two methods I have used for predicting the effect of environmental change on bird and mammal population trends. The first explores environmental correlates of observed population trends at a global scale; the second is a species level model which links species distribution models and population viability analyses in an attempt to capture the effect of environmental change on population dynamics.
Starts: Apr 23, 2018 1:00:00 PM
Title: New synthetic biology approaches for area-wide genetic control of insects
Speaker: Dr Nikolai Windbichler - Department of Life Sciences, Imperial College London (research profile)
Host: Professor Andrew Pomiankowski (email)
Venue: Medical Sciences 131 AV Hill (map)
Starts: Apr 25, 2018 12:00:00 PM
Title: Volume electron microscopic circuit reconstruction in larval zebrafish
Speaker: Dr Fabian Svara - Max Planck Institute of Neurobiology (website)
Venue: H O Schild Pharmacology LT, Medical Sciences (map)
Host: Dr Isaac Bianco (email) and Dr Chintan Trivedi (email)
Starts: Apr 25, 2018 1:00:00 PM
The Developmental Neurobiology Club is a seminar series that takes place four times a year, and is organised between UCL, KCL and the Crick, who host the seminars on a rotational basis.
The Club covers a broad range of topics within Neurosciences and sometimes even outside Neurosciences, despite its name. The next seminar will be taking place on Wednesday 25 April. Everyone welcome!
Starts: Apr 25, 2018 5:15:00 PM