Christodoulou Group

Protein Folding on the Ribosome

Our research

As nascent chains emerge from the ribosomal exit tunnel and into the cellular environment, the majority must fold into specific structures in order to function. Knowledge of how this folding process occurs, and how misfolding is avoided, is central to our understanding of living systems.

We use NMR spectroscopy together with biochemical and biophysical methods to study these co-translational folding processes with atomic resolution, in order to understand the fundamental principles of folding and misfolding within the cellular environment.

Wellcome Trust