Research in NPP is organised into four major themes: ‘Molecular and Cellular Neuroscience’, ‘Cellular and Circuit Neuroscience’, ‘Circuit and Systems Neuroscience’ and ‘Epithelial Biology’
NPP has an outstanding scientific heritage, built on the seminal contributions of many notable members of the former departments of Biophysics, Pharmacology and Physiology. These include James Black, Alfred Clark, John Gaddum, Paul Fatt, Archibald Hill, Andrew Huxley, Bernard Katz, Ricardo Miledi, and Heinz Otto Schild, whose work led to the development of modern, quantitative pharmacology, the first detailed descriptions of synaptic transmission, and the mechanistic understanding of ion channel function.
- Molecular and Cellular Neuroscience
Our work focuses on the study of ligand- and voltage-gated ion channels, G-protein-coupled receptors, and organelles, from structural and functional perspectives to their role in synaptic transmission during health and disease.
Professor Trevor G. Smart Molecular pharmacology of GABA and glycine receptor-ion channels Professor Shamshad Cockcroft Lipid signalling Professor Stuart Cull-Candy Calcium-permeable AMPARs and synaptic plasticity Professor Annette Dolphin Voltage-dependent calcium channels Dr Frances Edwards The hippocampus in health and disease Professor Mark Farrant Ionotropic GABA and glutamate receptor signalling Dr Jonathan Fry Steroid hormones Professor Alasdair Gibb Ion channel receptors and synaptic transmission Dr Matthew Gold Molecular basis of neuronal second messaging Dr Brian King Signalling of the purinoceptor family Professor Josef Kittler Cell biology of the synapse Professor Neil Millar Neuronal nicotinic acetylcholine receptors Dr Guy Moss Cellular and molecular biophysics Professor Paola Pedarzani Ion channels regulating neuronal excitability and firing properties Professor Ralf Schoepfer Molecules found in synapses
Professor Talvinder Sihra Mechanisms of neurotransmitter release Professor Lucia Sivilotti Nicotinic and glycine receptors Dr Martin Stocker Molecular pharmacology and physiology of potassium channels Dr Dean Willis Mechanisms of physiological and pathological inflammation Dr Anselm Zdebik Chloride/proton antiporters
- Cellular and Circuit Neuroscience
Our work focuses on the use of state-of-the-art optical-, electrical- and pharmacological techniques to reveal fundamental mechanisms of cellular and circuit function.
Professor Jonathan Ashmore Cellular mechanisms of hearing Professor David Attwell Neuron-glial interactions and brain energy supply Dr Marco Beato Glycinergic inhibition in the ventral spinal cord Dr Isaac Bianco Zebrafish circuits and behaivour Professor Maria Fitzgerald The developmental biology of spinal cord and cortical pain processing Professor Alexander Gourine Cardiovascular and respiratory neurophysiology Dr Andrew Macaskill Synaptic and circuit basis of emotional behaviour Professor Angus Silver Synaptic transmission and neural computation
- Circuit and Systems Neuroscience
Our work focuses on the use of state-of-the-art behavioural tasks, optogenetics, pharmacogenetics, in vivo imaging and electrophysiology to directly explore how cellular and circuit function generates and controls behaviour.
Dr Francesca Cacucci Hippocampal neural circuits Professor Anthony Dickenson Transmission and control of pain Dr Lorenzo Fabrizi Development of cortical function in humans Professor Giandomenico Iannetti Human sensory neuroscience Dr Tara Keck Cortical synaptic plasticity Professor Andy Ramage Modulation of chemical neurotransmission Professor Andreas Schaefer Neurophysiology of behaviour Dr Stefan Trapp Autonomic neuroscience and metabolic disease Professor Christopher Yeo How the cerebellum generates behaviour
- Epithelial Biology
Our work focuses on the investigation of the function of channels and transporters in epithelial membranes, in relation to homeostasis and disease.
Dr Brian King
Signalling of the purinoceptor family Dr Joanne Marks Regulation of epithelial transport in health and disease Dr Paola Vergani
CFTR in cystic fibrosis Dr Anselm Zdebik Chloride/proton antiporters