Neuroscience, Physiology and Pharmacology


Prof Angus Silver

Prof Angus Silver


Neuroscience, Physiology and Pharmacology
Medical Sciences Building, UCL


  • Professor of Neuroscience & Wellcome Trust Principal Research Fellow
    Neuro, Physiology & Pharmacology
    Div of Biosciences

Joined UCL


The brain gathers information about the body and the surrounding world, allowing it to build internal representations and to plan and execute movement. My lab works on how synapses, neurons and networks transmit and process such information and perform computations. The brain areas we investigate include the cerebellum and the sensory cortex.

The main aim of our work is to develop a mechanistic understanding of brain function that links the molecular, synaptic, neuronal and network levels. This requires a multidisciplinary approach that combines the most powerful experimental and theoretical methods available. To achieve this we both develop and apply new optical methods for measuring rapid signalling in 3D and new software tools for data acquisition, analysis and modelling. Application of these new experimental and theoretical approaches allows us to link neuronal mechanisms to information processing, thereby bridging different levels of description of brain function.

Award year Qualification Institution
1989 PhD
Doctor of Philosophy
University College London
1986 BSc Hons
Bachelor of Science (Honours)
Physical Sciences
Coventry Polytechnic


Biophysics|*|Brain slice physiology|*|Calcium|*|Calcium imaging|*|Cerebellum|*|Coding|*|Computational methods|*|Computational modelling|*|Computational models|*|Confocal microscopy|*|Dendrite|*|Electrophysiological recording techniques|*|Electrophysiology|*|Fluorescence microscopy techniques|*|Interneurons|*|Intracellular recording|*|Light microscopic techniques|*|Modelling|*|Multi-photon imaging|*|Neural Circuits/Networks|*|Neural signalling|*|Neuron|*|Neuroscience|*|Optical imaging|*|Other Not clinically oriented research|*|Patch-clamp recording|*|Synapse|*|Synaptic plasticity|*|Synaptic transmission, synaptic integration and information processing in neural networks|*|Transgenic mice