XClose

Neuroscience, Physiology and Pharmacology

Home
Menu

Prof Stuart Cull-Candy

Prof Stuart Cull-Candy

Address

Medical Sciences Building, University College London
Gower Street
London
WC1E 6BT

Appointments

  • Gaddum Chair of Pharmacology
    Neuro, Physiology & Pharmacology
    Div of Biosciences

Joined UCL

1975-10-01

Glutamateis recognized as being the most important excitatory neurotransmitter in the brain, transmitting information between nerve cells by activating AMPA- and NMDA type glutamate receptors (AMPARs and NMDARs) present at synapses. My lab focuses on understanding how glutamate receptors, their constituent subunits and associated molecules, shape fast synaptic transmission at individual synapses and in specific neural circuits. Early studies on ligand gated-channels suggested that neurotransmitters activate receptors with homogeneous channel properties. However, an altogether more versatile picture has emerged from work on mammalian central synapses. Comparison of different types of neurons has shown that they possess distinct complements of mRNAs coding for the various glutamate receptor subunits. The discovery of functional heterogeneity in glutamate receptor-channel properties is starting to explain one of the major issues in our understanding of central synaptic transmission - namely, how a single transmitter generates such enormous diversity in signalling between nerve cells, and within neural circuits. It is therefore a major challenge to understand precisely how individual receptor subunits influence basic properties of transmission at specific synapses, and how subunit diversity enables various dynamic changes in synaptic function. This is an essential step towards the understanding of signalling in the brain.The properties of AMPAR receptors are determined by their constituent building blocks (subunits). AMPAR subunit composition is thus critical in shaping fast excitatory synaptic transmission, and neuronal circuit behaviour. Of the AMPAR subunits, we are particularly interested in GluR2. This subunit is subject to posttranscriptional RNA editing which results in a single amino acid switch in its pore lining region. Editing at this site profoundly affects the properties of GluR2 containing AMPARs, making GluR2 a key determinant of AMPAR function.
Award year Qualification Institution
1974 PhD
Doctor of Philosophy
Synaptic Physiology
University of Glasgow
1971 MSc
Master of Science
Physiology
University College London
1969 BSc Hons
Bachelor of Science (Honours)
Zoology
University of London

Keywords

Biophysics|*|Cerebellum|*|Fluorescence microscopy techniques|*|Gliomas|*|Glutamate|*|Glutamate receptor channels underlying fast synaptic transmission in the brain|*|Interneurons|*|Ion channels|*|Ischaemic stroke|*|Molecular imaging|*|Motor Neurone Disease|*|Multiple sclerosis|*|NMDARs|*|Networks|*|Neural Circuits/Networks|*|Neural signalling|*|Oligodendrocytes|*|Patch-clamp recording|*|Pharmacology|*|Protein transport/localisation|*|Rapid agonist application|*|Recombinant protein expression|*|Single-channel recording|*|Synapse|*|Synaptic plasticity|*|Transgenic mice|*|calcium permeable AMPARs