The process of ageing (senescence) is now the predominant cause of illness and disease worldwide, and yet it remains poorly understood. The aim of research at the IHA is to discover the mechanisms of ageing as a means to discover the etiologies (causes) of the many diseases of ageing. These range from major causes of human mortality, such as cardiovascular disease (e.g. heart failure), cancer and chronic obstructive pulmonary disease (e.g. emphysema), to the numerous causes of late-life disability, such as dementia (e.g. Alzheimer's disease), osteoporosis (a cause of hip fracture) and macular degeneration (which causes loss of eyesight). To understand these diseases, we need to understand the biological basis of the ageing process. Arguably, this is key to being able to develop effective treatments to impede the development of late-life illness, and improve late life health.
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