The aim of our research is to discover genes and
mechanisms that determine the rate of ageing. We collaborate with
other laboratories to determine if these processes show evolutionary
conservation. Most of our work is conducted with the fruit fly Drosophila melanogaster.
Our work focuses particularly on the insulin/IGF-like signalling pathway, dietary restriction and resistance to stress. We are interested also in the physiological mechanisms that force organisms to make trade-offs, such as that between high nutrient intake and high reproductive rate, on one hand and slow ageing on the other.
Professor Dame Linda Partridge
works on the biology of ageing. Her research is directed to understanding
both how the rate of ageing evolves in nature and the mechanisms by which
healthy lifespan can be extended in laboratory model organisms. Her work
has focussed in particular on the role of nutrient-sensing pathways, such as
the insulin/insulin-like growth factor signalling pathway, and on dietary
She is the recipient of numerous awards, including the Royal Society’s Croonian Prize Lecture, and was honoured with a DBE for Services to Science in 2009. She is a Fellow of the Royal Society, the Academy of Medical Sciences and the American Academy of Arts and Sciences. She is Director of the Institute of Healthy Ageing at University College London and the founding director of the Max Planck Institute for Biology of Ageing in Cologne, Germany.
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