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Institute of Healthy Ageing

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Prof Dame Linda Partridge

Prof Dame Linda Partridge

Address

Institute of Healthy Ageing
Darwin Building
Gower Street
London
WC1E 6BT

Appointments

  • Professorial Research Fellow
    Genetics, Evolution & Environment
    Div of Biosciences

Joined UCL

2014-05-01

The aim of our research is to discover genes and mechanisms that determine the rate of ageing. We collaborate with other laboratories to determine if these processes show evolutionary conservation, most of our work is conducted with the fruit fly Drosophila and through comparison with C. elegans and then with the mouse. Our work focuses particularly on the insulin/IGF-like signalling pathway, dietary restriction and resistance to stress. We are interested also in the physiological mechanisms that force organisms to make trade-offs, such as that between high nutrient intake and high reproductive rate, on one hand, and slow ageing on the other.
Award year Qualification Institution
1974 DPhil
Doctor of Philosophy
Zoology
University of Oxford
1971 BA
Bachelor of Arts
Zoology
University of Oxford

Keywords

Ageing|*|Alzheimer's disease|*|Autophagy|*|Bioinformatic analysis|*|Bioinformatics|*|Brain|*|Cell culture|*|Dementia|*|Diabetes|*|Drosophila|*|Enzyme assays|*|Evolution|*|Fluorescence microscopy techniques|*|Gene expression|*|Gene expression profiling - tissue level|*|Genetic manipulation (including knockout/knockin)|*|Genetically encoded reporters/indicators|*|Genetics|*|Genomic analyses|*|Genomics|*|Light microscopic techniques|*|Linkage, mapping and positional cloning|*|MRI|*|Microarrays|*|Mitochondria|*|Modelling|*|Mouse|*|Neurodegeneration|*|Protein purification|*|Proteomics|*|Transgenic mice