Chair in Molecular Systems Biology
Genetics, Evolution & Environment
Div of Biosciences
The characteristics of organisms result largely from the dynamic interplay between DNA or RNA and the regulatory apparatus. The control of gene expression is fundamental to implement the information in the genome and to determine the properties of different organisms. Gene expression is regulated at multiple levels, and cells need to integrate external and internal cues and coordinate different regulatory levels to properly exert biological functions. We study transcriptional and post-transcriptional gene expression programmes during cellular proliferation, quiescence/ageing, and stress response using Schizosaccharomyces pombe as a model system. We apply multiple genetic and high-throughput approaches for systems-level understanding of regulatory networks and complex relationships between genotype, phenotype, and environment, including roles of genome variation and evolution, transcriptome regulation, and non-coding RNAs.
Doctor of Philosophy
Cell Biology and Genetics
Bachelor of Science
Jürg Bähler completed his PhD studies on meiotic chromosome metabolism at the University of Bern (Switzerland) under the supervision of Jürg Kohli. After short stays as a Research Associate in Japan and Switzerland, he worked as a Postdoctoral Fellow with John Pringle at the University of North Carolina (Chapel Hill, USA) and with Paul Nurse at the Imperial Cancer Research Fund (London, UK), studying cellular morphogenesis and cell-cycle regulation. In 2000, Bähler joined the Wellcome Trust Sanger Institute (Hinxton, UK) as a Group Leader, and in 2009 was appointed as a Professor of Systems Biology at University College London.