Patricia Salinas Laboratory
The primary aim of our research is to elucidate the molecular mechanisms that regulate synapse formation, maintenance and function in the vertebrate nervous system.
We study the signalling pathways that regulate the assembly and disassembly of synapses, and their impact on animal behaviour. For our studies, we work with cultured neurons and in vivo, using mice deficient in Wnt signalling.
We are particularly interested in the hippocampus, an area of the brain implicated in learning and memory.
Recently, we have undertaken the study of synaptic stability in the striatum, a brain area that regulates motor coordination and movement, and is affected in Parkinson’s disease.
We use a multidisciplinary approach that combines the use of cellular and molecular biology techniques with the latest technology in live cell imaging, electrophysiology and behavioural analyses.