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Cell and Developmental Biology

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Dr Masazumi Tada

Dr Masazumi Tada

Address

Rm 105, Anatomy building
Department of Cell & Developmental Biology, UCL
Gower Street
London
WC1E 6BT

Appointments

  • Reader in Developmental and Cellular Biology
    Cell & Developmental Biology
    Div of Biosciences

Joined UCL

2000-10-01

Research Themes

I am interested in cellular and molecular mechanisms underlying co-ordinated and directional cell movements. The primary focus is on morphogenetic movements occurring during gastrualtion using the zebrafish as a model system; epiboly, convergence/extension and anterior migration of mesodermal cells. Since we showed that Wnt11 is an important regulator of convergence/extension movements during gastrulation in vertebrates, it has been evident that this ligand acts in a pathway related to the planar cell polarity (PCP) pathway in Drosophila. Recently, the core PCP genes have been also implicated in regulating a variety of morphogenetic processes in vertebrates including neural tube closure, orientation of cochlear hair cells, migration of facial motorneurons and ciliogenesis. Current projects are a) Understanding mechanisms by which core PCP proteins regulate gastrulation movements in zebrafish; b) Identifying and characterising genetic pathways that act in or in parallel with the PCP pathway during gastrulation; c) Exploring other biological processes that are regulated by the PCP genes and their genetic modifiers.
Award year Qualification Institution
1990 PhD
Doctor of Philosophy
Applied Biochemistry
University of Tsukuba
1986 MSc
Master of Science
Physical Sciences
University of Tsukuba
1983 BSc
Bachelor of Science
Applied Biochemistry
University of Tsukuba

Keywords

Cell movements in early development|*|Cell tracking|*|Genetic screens|*|Molecular imaging|*|Spina bifida|*|Time-lapse imaging|*|Zebrafish