The Bähler, Balloux, and Dessimoz labs have published a paper identifying structural variants in fission yeast and describing their effects on multiple quantitative traits—including winemaking, gene expression and intrinsic reproductive isolation.
Read the paper in Nature Communications and the story behind the paper in the Dessimoz Lab Blog post:
Publication date: 17 February 2017
New paper from the Patel lab published in Cell Reports identifies Ca2+ as a key regulator of physical junctions between organelles
Endosomes form junctions with the endoplasmic reticulum (ER) but how such proximity is regulated is unclear. The paper by joint first authors Bethan Kilpatrick and Emily Eden shows that release of Ca2+ by an endosomal ion channel facilitates inter-organellar coupling to temper signals mediated by an internalised growth factor. Endosome-ER contact sites thus emerge as Ca2+-dependent signalling hubs.
Publication date: 16 February 2017
Raising Horizons is a temporary photographic exhibition organised by TrowelBlazers in collaboration with photographer Leonora Saunders. It features contemporary female scientists photographed as their historical counterparts to draw attention to the diversity of women in science and the often underappreciated contributions of women to science.
Division of Biosciences is proud to announce Professor Anjali Goswami is one of the participants photographed dressed as turn-of-the-century Dorothea Bate, a mammalian palaeobiologist and the first female scientist employed by the NHM.
Date: 1-28 February 2017
Time: 9.30 - 5.30
Venue: the Geological Society Lower Library
Further exhibition details can be found on the Geological Society website: https://www.geolsoc.org.uk/Raising-Horizons
Publication date: 10 February 2017
Obituary E. B. Robson, PhD. Galton Professor of Human Genetics, University College London (1928- 2016) died July 18th 2016
Bette Robson was an important figure in the development of our understanding of human genetics and gene mapping for a period of more than 40 years. She retired from the Galton Chair in 1993.
After obtaining a 1st Class Hons BSc in Zoology, University of Durham her first research was done in the Galton Laboratory at University College London (UCL) in 1950-53. Lionel Penrose was Head of Department and she did a PhD on the knotty topic of human birth weight and stabilising selection, which is still a significant area of research. This was followed by a year with a Rockefeller Travelling Fellowship in the USA, principally at Columbia University, NYC with Professors L. C. Dunn and T. Dobzhansky. After returning to the Galton laboratory She also learnt a great deal from the very wide circle of scientists, doctors and others who frequented ‘The Galton’ in those days. She moved from UCL to work with Harry Harris at the London Hospital Medical School in 1957, to broaden her experience and develop new techniques to identify human genes. This work was based on Oliver Smithies’ new invention of starch gel electrophoresis and genetic analysis of human haptoglobins.
This work was very successful and led directly to the formation of a new Medical Research Council Unit, in Kings College London, in 1962, with Harry Harris as Unit director. Bette introduced two-dimensional electrophoresis of human pseudo-cholinesterase (E1) and discovered a new polymorphism (Nature 1962, 196, 1296-1298). Within a few years she also had evidence of linkage between this enzyme (E1) and the transferrin (Tf) locus (Ann Hum Genet. 1966, 29, 325). Also with David Hopkinson, she set up a large international consortium to carry out linkage analysis (Am. J. Hum. Genet. 1965, 17,109) on the recently discovered red cell acid phosphatase polymorphism (Nature 1963. 163,199). Working directly with Harry Harris she carried out fundamental new work on the genetics of human placental alkaline phosphatase (Nature 1965. 207, 1257; Ann Hum. Genet. 1967. 30)
At about this time, Lionel Penrose retired and Harry Harris was appointed Galton Professor at UCL. A new Research building at UCL, Wolfson House, funded by the Wolfson Foundation, provided new homes for the Galton laboratory and the MRC Human Biochemical Research Unit in UCL.
Bette was delighted to move from Kings College London and was able to continue extensive gene assignment and gene mapping projects which involved widespread collaborations. She published one of the two first papers that mapped a gene to a human autosome in 1969, the assignment of the alpha locus of the human haptoglobin gene to chromosome 16 (Nature 1969. 223, 1163-5). There were also many new collaborations within UCL as other colleagues and collaborators moved in to share the excitement and the new laboratories.
For example, during this period Bette enjoyed extra help from Peter Cook with his ideas and expertise in Gene Mapping, Gerald Corney brought expertise on twins and family studies and the MRC Blood Group Unit (Directors Ruth Sanger & Patricia Tippet) moved in to Wolfson House with extra knowledge and resources. There were also many connections with ‘outside’ friends such as Walter Bodmer’s Unit at ICRF & Oxford, John Evans in Edinburgh and numerous other research groups in the UK and overseas, as gene mapping projects began to expand across the world.
Harry Harris remained in post till 1976 when he moved to Philadelphia and in 1978 Bette became Galton Professor. Over the years, Bette always supported the International Human Gene Mapping (HGM) workshops which brought together all the relevant information every 2 years from 1973 to 1991, by submitting data, chairing the overall summaries for many different chromosomes and robustly participating in the discussions. She also enjoyed the less formal social aspects of these remarkable gatherings. Apart from the exciting new science at the Los Angeles work shop in 1982 she was delighted to see so many lively young scientists attending. She encouraged her own post graduate students and young postdocs to go to these workshops and present their own data. Recent letters from former students have commented that her supervision was rigorous but in the end very supportive and enabling. Senior colleagues were many times guided by the clear critical thinking and sharp wit of her advice. In 1988 Bette became a member of the founding council of the Human Genome Organisation (HUGO) described at the time as ‘The UN of the Human Genome’ (Genomics 1989 5:385).
She also took on extra responsibilities at UCL for organising undergraduate and postgraduate teaching of Human Genetics in UCL and mentoring students. She enjoyed advising and helping these students and many of them stayed on in UCL and remained good friends for years. She also enjoyed cultural interests outside science and was happy to encourage this both in staff and students. She had a love for Italy and all things Italian with many Italian friends. She was an enthusiastic gardener at home and agreed to serve as one of the original Trustees of the Royal Botanic Gardens (RBG) at Kew in October 1983, when the Board was first created, and served there for 8 years.
Publication date: 10 February 2017
Nick Lane receives the Michael Faraday Award 2016 and presents the Faraday Lecture "Why is Life the way it is?
The Faraday Medal is awarded in recognition of Nick's excellent work in communicating science to UK audiences and was presented following his Prize Lecture given at the Royal Society last night (1 Febraury 2017)
Publication date: 2 February 2017
Of all 504 primate species, the rarest and most vulnerable is found only on one tropical island at the southern tip of China. The majestic and enigmatic Hainan gibbon is confined to a single small patch of forest. Only around 25 remain.
Publication date: 20 January 2017
Congratulation to Dr Lucy Van Dorp on the successful defence of her thesis entitled 'Investigating processes driving genetic diversity in human populations using dense haplotypes'
Publication date: 19 January 2017
The global map of alien bird species has been produced for the first time by a UCL-led team of researchers. It shows that human activities are the main determinants of how many alien bird species live in an area but that alien species are most successful in areas already rich with native bird species.
Publication date: 19 January 2017
Flies with a history of eating a high sugar diet live shorter lives, even after their diet improves. This is because the unhealthy diet drives long-term reprogramming of gene expression, according to a UCL-led team of researchers
Full story on UCL News Site
Publication date: 11 January 2017
The paper, published in Nature Communications 2016 Mar 1; 7;10816 “A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features” is the result of work carried by members of the Ruiz Linares group in GEE and collaborators.
Publication date: 22 December 2016
Professor E. B. Robson (1928-2016), former Galton Professor, died earlier this year (18 July 2016). We hope to publish an obituary in 2017 and would appreciate recollections from those who knew her. Please contact Professor Sue Povey on email@example.com
(Accompanying image is from Bette’s path-breaking paper with Harry Harris in 1965 (Nature 207, 1257-1259) using gel electrophoresis to uncover alleles of the human alkaline phosphatase gene).
Publication date: 21 December 2016
Congratulations to Dr Arunas Radzvilavicius on the successful completion of his PhD. Arunas, jointly supervised by Professor Andrew Pomiankowski and Dr Nick Lane, successfully defended his thesis "Evolutionary Dynamics of Mitochondrial Mutations in the Origin and Development of Eukaryotic Sex" subject to minor corrections. The examiners were Prof Richard Goldstein (UCL) and Professor Tom Richards (Exeter).
Publication date: 13 December 2016
CDB's Szabadkai team receives Wellcome Trust Pathfinder Award to study mitochondrial subtypes of breast cancer
Gyorgy Szabadkai (UCL Department of Cell and Developmental Biology) together with Robert Stein (UCLH, UCL Cancer Institute) and Mariia Yuneva (Francis Crick Institute) and Kevin Bryson (UCL Computer Sciences) as CoI, has received a Wellcome Trust Pathfinder Award to develop a mitochondrial gene expression based biomarker to inform on chemosensitivity of luminal breast tumours.
Publication date: 28 November 2016
The UCL-Birkbeck MRC Doctoral Training Programme provides state-of-the-art PhD training and exploits the unique research strengths and training infrastructure of UCL and Birkbeck.
There are four strategic themes including the Fundamental Mechanisms of Disease. Each theme supports a cohort of PhD students, PIs and training opportunities.
Deadline for applications: Friday 13 January 2017
Publication date: 24 November 2016
Alex Stewart along with a scientific team University of Pennsylvania, Yale, Princeton and Indiana University has received an award from the Defense Advanced Research Projects Agency (DARPA) to develop and validate reproducible methods for studying human social behavior.
DARPA is an agency of the U.S. Department of Defense that invests in breakthrough technologies to support national security. The award is part of DARPA’s new Next Generation Social Science program, or NGS2, which aims to revolutionize the speed, scale and rigor with which social science is performed.
The grant provides the multi-disciplinary team with $2.95 million for two years, with a possible additional $2.3 million for a subsequent one-and-a-half years, dependent on progress, to further the goals of the NGS2 program, a key one being to develop a deeper understanding of the factors that drive the emergence or collapse of collective identity in human populations.
Alexander Stewart, University College London.
Joshua B. Plotkin, University of Pennsylvania
Erol Akçay, University of Pennsylvania
David Rand, Yale University;
Simon Levin, Princeton University;
Johan Bollen, Indiana University
Publication date: 16 November 2016
Co-Developing a method for assessing the psychosocial impact of cultural interventions with displaced people: towards an integrated care framework
Global Challenge Research Fund project funded by the Economic and Social Research Council and the Arts and Humanities Research Council (2016-2018).
Publication date: 4 November 2016
We are delighted to announce that Seirian Sumner, formally a Senior Lecturer at Bristol, has joined CBER (the Centre for Biodiversity and Environment Research) as a Reader in Behavioural Ecology. Seirian’s research seeks to to explore the interface between behavioural ecology, biodiversity and conservation.
Publication date: 28 October 2016
Evolutionary consequences of behavioral diversity - how access to more complex social interactions can cause a population to evolve less cooperative behaviours
Alex Stewart and collaborators Todd Parsons (Université Pierre et Marie Curie in Paris) and Joshua Plotkin (University of Pennsylvania in Philadelphia) publish their findings in a paper to come out this week in Proceedings of the National Academy of Sciences.
Publication date: 25 October 2016
Publication date: 24 October 2016
Dr Newbold's research seeks to understand how habitat loss and climate change together impact the structure and diversity of ecological communities. Habitat loss and climate change are the biggest threats to biodiversity, but the extent to which they might interact in their impacts on biodiversity remains very poorly understood.
Publication date: 24 October 2016
The EMBO Young Investigator Programme provides support for researchers under forty years of age who have set up their first laboratories in the past four years
Christophe is one of 25 life scientists selected to join the programme this year who join a network of 74 current and 382 past Young Investigators and who represent some of the best young group leaders in the life sciences in Europe and beyond.
Publication date: 21 October 2016
The award will support a post-doc in Tim Blackburn’s group, Professor of Invasion Biology, CBER. The study will seek to untangle evolutionary and human historical contexts in the introduction and spread of alien bird species.
Publication date: 20 October 2016
Dr Lorenzo Fabrizi (UCL) and Dr Tomoki Arichi (KCL) have been awarded a Merit Abstract Award from the Organization for Human Brain Mapping at their annual meeting for their study of spontaneous neuronal activity in prematurity using simultaneous EEG and fMRI.
The Organization for Human Brain Mapping (OHBM) is the primary international organization dedicated to using neuroimaging to discover the organization of the human brain.
Publication date: 7 October 2016