New paper from Claudio Stern’s lab in PNAS: “Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells”
3 January 2018
During development, various organ systems are set aside from the rest of the embryo as a result of “induction” from specific signalling tissues, called organizers. This paper reveals that inductions of the nervous system and of cranial sensory placodes, by different organizers, begin by the same step, which resembles the pluripotent state of embryonic stem cells. This suggests that the first event in specifying organ systems is an “erasure” of information that reverts cells back to an earlier developmental state before redirecting them to their final fate.
Authors: Katherine E. Trevers, Ravindra S. Prajapati, Mark Hintze, Matthew J. Stower, Anna C. Strobl, Monica Tambalo, Ramya Ranganathan, Natalia Moncaut, Mohsin A. F. Khan, Claudio D. Stern, and Andrea Streit.