New paper by Danny Filer and colleagues from the UCL Institute of Healthy Ageing
30 November 2017
Inhibiting RNA polymerase III prolongs lifespan in flies and worms, and survival in budding yeast, report Danny Filer and colleagues from the UCL Institute of Healthy Ageing in a recent Nature publication.
The study, performed in collaboration with researchers at University of Kent and University of Groningen, found that moderate inhibition of RNA polymerase III increases animal lifespan and improves some indices of heath. This conserved eukaryotic enzyme provides short, non-coding RNAs required for translation and other fundamental cellular processes. Interestingly, its inhibition appears to explain the action of rapamycin, a drug that extends lifespan of a number of distantly related species. Understanding how inhibition of this polymerase acts on animal physiology may provide new targets for therapies of age-related disease.
Read full paper: RNA polymerase III limits longevity downstream of TORC1
Authors: Danny Filer, Maximillian A. Thompson, Vakil Takhaveev, Adam J. Dobson, Ilektra Kotronaki, James W. M. Green, Matthias Heinemann, Jennifer M. A. Tullet & Nazif Alic