Seminar - Dr Mark van der Giezen - 4 October 2017

Start: Oct 04, 2017 12:00 PM
End: Oct 04, 2017 01:00 PM

Title: Biochemical and evolutionary peculiarities of the hyper-prevalent parasitic eukaryote Blastocystis
Speaker: Dr Mark van der Giezen - University of Exeter (research profile)
Host: Professor John Allen (email)
Venue: TBC

Abstract: Mitochondria are the main of sites of ATP generation in eukaryotes. These organelles are derived from a bacterial endosymbiont that entered a host cell over 1.5 billion years ago. Comparative genetics has made it clear that the mitochondrion is monophyletic in origin. Therefore, the mitochondrial endosymbiont evolved independently in various aerobic and anaerobic lineages. This has resulted in an assemblage of heterogeneous organelle variants including classic text-book mitochondria, hydrogenosomes and mitosomes. Recently, studies investigating less well-studied eukaryotic groups have resulted in the realisation that mitochondrial diversity is even more fluid than previously thought. In this talk I will provide an overview of the field of mitochondrial evolution using examples of the cell biological and biochemical variety found in various anaerobic microbial eukaryotes, with an emphasis on the human intestinal pathogen Blastocystis.

See also:

E. Gentekaki, B.A. Curtis, C.W. Stairs, V. Klimeš, M. Eliáš, D.E. Salas-Leiva, E.K. Herman, L. Eme, M.C. Arias, B. Henrissat, F. Hilliou, M.J. Klute, H. Suga, S.-B. Malik, A.W. Pightling, M. Kolisko, R.A. Rachubinski, A. Schlacht, D.M. Soanes, A.D. Tsaousis, J.M. Archibald, S.G. Ball, J.B. Dacks, C.G. Clark, M. van der Giezen and A.J. Roger (2017) Extreme genome diversity in the hyper-prevalent parasitic eukaryote Blastocystis PLoS Biology 15(9) e2003769

C.W. Stairs, L. Eme, M.W. Brown, C. Mutsaers, E. Susko, G. Dellaire, D.M. Soanes, M. van der Giezen, A.J. Roger (2014) A SUF Fe-S cluster biogenesis system in the mitochondrion-related organelles of the anaerobic protist Pygsuia. Curr. Biol., DOI: http://dx.doi.org/10.1016/j.cub.2014.04.033

M. Müller, M. Mentel, J.J. van Hellemond, K. Henze, C. Woehle, S.B. Gould, R.Y. Yu, M. van der Giezen, A.G. Tielens and W.F. Martin (2012) Biochemistry and evolution of anaerobic energy metabolism in eukaryotes. Microbiol. Mol. Biol. Rev., 76, 444-495

van der Giezen laboratory website